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Synthesis and Antitumor Activity of 2-Aryl-1, 2, 4-Triazolo[1, 5-a] Pyridine Derivatives

[ Vol. 6 , Issue. 2 ]


Xuefen Tao and Yongzhou Hu   Pages 65 - 69 ( 5 )


A novel series of 2-aryl-1, 2, 4 – triazolo [1, 5-a] pyridine derivatives have been synthesized and evaluated for their cytotoxic activities in vitro against Human ovarian cancer cell line (HO-8910) and Human liver cancer cell line (Bel 7402). Most compounds showed high or mediate activity against the cancer cell lines when compared with Cisplatin. Two of them were tested the apoptosis on Bel 7402.


Synthesis, antitumor activity, 2- aryl-1, 2, 4, –, triazolo [1, 5-a] pyridine


ZJU-ENS Jiont Laboratory of Medicinal Chemistry, School of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

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