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Synthesis, Testing and Structure-Activity Studies on a Library of 5-HT4 Ligands

[ Vol. 6 , Issue. 6 ]

Author(s):

Amir Hanna-Elias, David T. Manallack, Alla Levit, William Nguyen, Fadi Ayad, Glen Perera, Marina Shapiro, Helen R. Irving, Ian M. Coupar and Magdy N. Iskander   Pages 344 - 354 ( 11 )

Keywords:

5-HT4 ligands, radioligand binding, CoMFA, pharmacophore, molecular modelling, tetrahydroquinoline, gastroesophageal reflux disease, irritable bowel syndrome, TopCount Microplate Scintillation Counter, cisapride, metoclopramide, NMR spectrometer, Micromass Platform II single quadrupole mass spectrometer, electrospray, column chromatography

Affiliation:

Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.



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