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Synthesis and Antiviral Evaluation of Bisnoradamantane Sulfites and Related Compounds

[ Vol. 7 , Issue. 2 ]

Author(s):

Elena Valverde, Eva Torres, Salvador Guardiola, Lieve Naesens and Santiago Vazquez   Pages 135 - 140 ( 6 )

Abstract:


The reaction of a series of 1,2-diols with thionyl chloride led to bisnoradamantane sulfites in very good yields. The reaction has also been applied to related polycyclic scaffolds. The compounds have been tested for antiviral activity but none of them showed to be active. Several attempts to generate and trap SO from these polycyclic sulfites have been unsuccessful.

Keywords:

Antiviral activity, bisnoradamantanes, polycyclic compounds, sulfites, sulfur monoxide, vesicular stomatitis virus, 1,2-diols, thionyl chloride, adamantane, ring-contracted analogs, memantine, rimantadine

Affiliation:

Laboratori de Quimica Farmaceutica (Unitat Associada al CSIC); Facultat de Farmacia and Institute of Biomedicine (IBUB), Universitat de Barcelona, Av. Diagonal, 643, 08028 Barcelona, Spain.



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