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Labeling Strategies with F-18 for Positron Emission Tomography Imaging

[ Vol. 7 , Issue. 5 ]

Author(s):

Yonghong Gu, Dong Huang, Zhiguo Liu, Jiaguo Huang and Wenbin Zeng   Pages 334 - 344 ( 11 )

Abstract:


The labeling of probes with fluorine-18 [18F, β(+); 96.7%] continues to play a considerably important role in the development of positron emission tomography (PET) as a modality for both clinical research and clinical diagnoses. This review summarizes the strategies and recent developments in the fluorine-18 labeling of probes for PET imaging. Problems and issues relating to the practical production of fluorine-18 currently in widespread use are also discussed.

Keywords:

Probe, fluorination, F-18, positron emission tomography (PET), molecular imaging, labeling chemistry, radiotracer, radiochemists, radiopharmaceuticals, solid-phase, microfluidics, microwave chemistry

Affiliation:

School of Pharmaceutical Sciences, Central South University, Changsha 410013, P. R. China.



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