Yonghong Gu, Dong Huang, Zhiguo Liu, Jiaguo Huang and Wenbin Zeng Pages 334 - 344 ( 11 )
The labeling of probes with fluorine-18 [18F, β(+); 96.7%] continues to play a considerably important role in the development of positron emission tomography (PET) as a modality for both clinical research and clinical diagnoses. This review summarizes the strategies and recent developments in the fluorine-18 labeling of probes for PET imaging. Problems and issues relating to the practical production of fluorine-18 currently in widespread use are also discussed.
Probe, fluorination, F-18, positron emission tomography (PET), molecular imaging, labeling chemistry, radiotracer, radiochemists, radiopharmaceuticals, solid-phase, microfluidics, microwave chemistry
School of Pharmaceutical Sciences, Central South University, Changsha 410013, P. R. China.