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Synthesis and DPPH Radical Scavenging Activity of 5-Arylidene-N,Ndimethylbarbiturates

[ Vol. 7 , Issue. 3 ]


Khalid Mohammed Khan, Momin Khan, Muhammad Ali, Muhammad Taha, Abdul Hameed, Sajjad Ali, Shahnaz Perveen and M. Iqbal Choudhary   Pages 231 - 236 ( 6 )


Twenty-four derivatives of N,N-dimethylbarbituric acid 1-24 were screened for their DPPH radical scavenging activity. These compounds showed an excellent antioxidant activity. A structure-activity relationship has been discussed, while all the synthetic compounds were characterized by spectroscopic techniques and elemental analysis.


DPPH Radical scavengers, N,N-dimethylbarbiturates, N,N-dimethylbarbituric acid, DPPH, scavenging activity, antioxidant, spectroscopic techniques, elemental analysis, Barbituric acid, n-propyl gallate


H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.

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