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Design, Synthesis of Novel Quinazolone Alkaloids Derivatives as Potential Antitumor Agents

[ Vol. 7 , Issue. 4 ]

Author(s):

Youguang Zheng, Min Sun, Yi Liu, Mingdong Li and Min Ji   Pages 295 - 300 ( 6 )

Abstract:


Several novel quinazolone alkaloids derivatives were synthesized. Some of the target compounds were determined against human prostate cancer DU145 and pancreatic cancer Miacapa2 cells in vitro. The entire compounds had been identified by 1HNMR, 13CNMR, IR, MS and EA.

Keywords:

Quinazolone alkaloids, human pancreatic cancer, Miacapa2, EGFR, X-ray crystal structure, prostate cancer, EA, MS, IR, 13CNMR, 1HNMR

Affiliation:

School of Chemistry&Chemical Engineering, Southeast University, Nanjing 211189, China.



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