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Design, Synthesis and Antitumor Activity of Novel D-Glucuronic Acid Derivatives

[ Vol. 7 , Issue. 6 ]

Author(s):

Ahmed O. H. El-Nezhawy, Frady G. Adly, Ahmed F. Eweas, Atef G. Hanna, Yehya M. El-Kholy, Shahenaz H. El-Syed and Tarek B. A. El-Naggar   Pages 624 - 638 ( 15 )

Abstract:


A series of D-glucuronic acid derivatives were chemically synthesized including acetylated and deacetylated glucuronamides, as well as N-glucuronides starting from the D-glucuronic acid itself by means of protection/deprotection, activation and condensation protocols. Structure elucidation of all products along with optimization of the synthetic steps is described. The synthesized compounds were evaluated for their in vitro antitumor activity against MCF-7, TK-10 and UACC-62 cell lines. The compounds 4, 5, 7, 8, 14, 16 and 18 were the most active against TK-10 cell line. On the other hand, the most active compounds against the MCF-7 cell line were 9, 18 and 20. However, compounds 7-10 13-15 and 17 were the most active against the UACC-62 cell line.

Keywords:

D-glucuronic acid, D-glucuronamide, amide linkage, antitumor, TK-10, MCF-7, UACC-62, condensation protocols, chemically synthesized, uncontrolled cell proliferation

Affiliation:

Chemistry of Natural and Microbial Products Department, National Research Center, Dokki, Cairo,Egypt; Pharmaceutical Chemistry Department, College of Pharmacy, TaifUniversity, KSA.



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