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Synthesis and Evaluation of Biological Activities of a Series of (6-substitutedbenzothiazol-2-yl)acrylamides

[ Vol. 7 , Issue. 6 ]

Author(s):

Nguyen-Hai Nam, Phan Thi Phuong Dung, Doan Thanh Hieu, Le Hoang, Tran Thi Hien, Tran The Cuong and Phan Dinh Chau   Pages 727 - 731 ( 5 )

Abstract:


A series of simple (6-substitutedbenzothiazol-2-yl)acrylamides was synthesized and evaluated for cytotoxicity and antimicrobial effects. All six compounds displayed very significant cytotoxicity against four cancer cell lines tested including A549 (a human lung cancer cell line), Hela (a human ovarian cancer cell line), MCF7 (a human breast cancer cell line), and even MCF7-ADR (adriamycin-resistant human breast cancer cell line), with IC50 values in microgram/ml range and as low as 0.66 μg/ml. The synthesized compounds also exhibited some antifungal effects against Apergillus niger.

Keywords:

kwd, Benzothiazole, cytotoxicity, synthesis, acrylamides, (6-substitutedbenzothiazol-2-yl), and antimicrobial effects, antifungal effects, Apergillus niger, nucleophilic, 2-aminobenzothiazole

Affiliation:

Department of Pharmaceutical Chemistry, Hanoi University of Pharmacy, 13-15 Le Thanh Tong, Hanoi, Vietnam.



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