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Discovery ofβ-Glucosidase Inhibitors from a Chemically Engineered Extract Prepared through Ethanolysis

[ Vol. 8 , Issue. 1 ]

Author(s):

I. Ayelen Ramallo, Manuel Gonzalez Sierra and Ricardo L. E. Furlan   Pages 112 - 117 ( 6 )

Abstract:


A series of vegetal extracts have been chemically altered by ethanolysis. The effect of the reaction on the inhibition of the enzyme β-glucosidase properties of the mixtures was studied using thin layer chromatography (TLC) with biodetection. Glucosidase inhibitory activity guided fractionation of one of the produced chemically engineered extracts led to the isolation of apigenin and ethyl p-cumarate. Both compounds were generated during the chemical modification step.

Keywords:

Chemically engineered extracts, Ethanolysis, TLC biodetection, -glucosidase inhibition, ethyl p-cumarate, thin layer chromatography, bromine, arylsulfonyl chlorides, hydrazine, antifungal

Affiliation:

Farmacognosia, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario,Suipacha 531, S2002LRK Rosario, Argentina.



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