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Synthesis and Preliminary Antihyperlipidaemic Activities Evaluation of Andrographolide Derivatives

[ Vol. 8 , Issue. 2 ]

Author(s):

Bin Wang, Chunlei Tang, Yaodan Han, Ruzhou Guo, Hai Qian and Wenlong Huang   Pages 293 - 298 ( 6 )

Abstract:


Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.

Keywords:

andrographolide, antihyperlipidaemic activities, derivatives, synthesis, Cholesterol, hyperlipidemia, Green tea, Artichoke, Guggul, plants

Affiliation:

School of Pharmacy, China Pharmaceutical University, Nanjing 210009, People’s Republic of China.



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