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Synthesis and Preliminary Antihyperlipidaemic Activities Evaluation of Andrographolide Derivatives

[ Vol. 8 , Issue. 2 ]


Bin Wang, Chunlei Tang, Yaodan Han, Ruzhou Guo, Hai Qian and Wenlong Huang   Pages 293 - 298 ( 6 )


Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.


andrographolide, antihyperlipidaemic activities, derivatives, synthesis, Cholesterol, hyperlipidemia, Green tea, Artichoke, Guggul, plants


School of Pharmacy, China Pharmaceutical University, Nanjing 210009, People’s Republic of China.

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