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Substituted Urea Derivatives: A Potent Class of Antidepressant Agents

[ Vol. 8 , Issue. 3 ]


Shahnaz Perveen, Sana Mustafa, Muhammad A. Khan, Ahsana Dar, Khalid M. Khan and Wolfgang Voelter   Pages 330 - 336 ( 7 )


A series of fourteen (14) N-nitrophenyl-N'-(alkyl/aryl)urea and symmetrical 1,3-disubstituted urea derivatives were synthesized and evaluated for their antidepressant activity in mice. Among them, N-(4-nitrophenyl)-N'-(1'-phenylethyl)urea (1), demonstrated profound antidepressant property as reflected by significant reduction in the immobility time (89.83%), whereas compounds 2-6 showed activity values between 36 to 59% which were also larger than the standard phenelzine. Compounds 7-9 were less effective in reducing the immobility period of mice 26.20 to 31.01%). This variable magnitude of antidepressant activity appears to be related to the position of the nitro group to the parent molecules 1, 2, and 8. Compound 1 with the nitro group at para position showed to be the most effective antidepressant. However, the activity declined, if the nitro is attached to ortho and meta positions.


Amines, Antidepressant, Disubstituted urea derivatives, Isocyanate, Symmetrical urea, Tail suspension test (TST), carbamates, lipoproteinelevating, cholinergic agents


PCSIR Laboratories Complex, Karachi, Shahrah-e-Dr. Salimuzzaman Siddiqui, Karachi-75280, Pakistan.

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