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Synthesis and Antiglycation Activity of Kaempferol-3-O-rutinoside (Nicotiflorin)

[ Vol. 8 , Issue. 3 ]


Sajan Lal Shyaula, Ghulam Abbas, Hina Siddiqui, Samina A. Sattar, M. Iqbal Choudhary and Fatima Z. Basha   Pages 415 - 420 ( 6 )


Kaempferol-3-O-α-L-rhamanopyranosyl-(1'''-6'')-β-D-glucopyranoside (1) (Nicotiflorin or kaempferol-3-O-rutinoside), isolated from the aerial parts of Osyris wightiana Wall. ex Wight, exhibited a potent antiglycation activity in vitro. A short and efficient route to kaempferol-3-O-rutinoside (1) is also described in this paper. To study the structure-activity relationship, few other derivatives of kaempferol were also evaluated for their antiglycation activity. Moreover the cytotoxicity analysis was also performed for these compounds. The Structure-Activity Relationship (SAR) studies showed that sugar derivatives of kaempferol possess a promising antiglycation activity.


Kaempferol-3-O-rutinoside, Osyris wightiana Wall. ex Wight, antiglycation activity, cytotoxicity, Diabetes, Nicotiflorin, rhamanopyranosyl , glucopyranoside, cytotoxicity, anaphylactic, immunomodulatory


H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.

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