E-Pub Full Text Articles

Novel Hybrids of Pyrazolidinedione and Benzothiazole as TZD Analogues. Rationale, Design, Synthesis and In Vivo Anti-Diabetic Evaluation

Author(s): Michelyne Haroun*
Pages: 1-10 (10)
Advances in Structural Biology of ACE and Development of Domain Selective ACE-inhibitors

Author(s): Maja Polakovičová* and Josef Jampílek
Pages: 1-14 (14)
Synthesis, Biological Evaluation and Molecular Dynamics Simulation Studies of Novel Diphenyl Ethers

Author(s): Amol B. Khade, Sidhartha S. Kar, A Cinu Thomas , Ashutosh Tiwari, Mradul Tiwari, K. E. Vandana , Pritesh Bhat, G. Varadaraj Bhat and G. Gautham Shenoy*
Pages: 1-15 (15)
Bicycloheptylamine-Doxorubicin Conjugate: Synthesis and Anticancer Activities in σ2 Receptor-Expressing Cell Lines

Author(s): Mohammed A. Alamri, Zeynep Ates-Alagoz and Adeboye Adejare*
Pages: 1-10 (10)
New Copper Compounds with Antiplatelet Aggregation Activity

Author(s): Mirthala Flores-Garcia, Juan Manuel Fernández-G, Cristina Busqueta-Griera, Elizabeth Gomez, Simon Hernandez-Ortega, Jean Christian Daniel Lamothe-Flores, Virginia Gomez-Vidales, Ana Maria Mejia-Dominguez, Eduardo Angles-Cano and Aurora de la Pena-Diaz*
Pages: 1-13 (13)
Design and Synthesis of New Sulfonamides–Based Flt3 Inhibitors

Author(s): Reem Fawaz Abutayeh, Jehad Almaliti and Mutasem O. Taha*
Pages: 1-10 (10)
Cytotoxicity, Pro-apoptotic Activity and in silico Studies of Dithiocarbamates and their Structure Based Design and SAR Studies

Author(s): Syeda Shamila Hamdani, Bilal Ahmad Khan*, Shahid Hameed, Faisal Rashid, Sumera Zaib, Khalil Ahmed, Ehsan Ullah Mughal and Jamshed Iqbal*
Pages: 1-11 (11)
Synthesis, Anticancer Evaluation and Synergistic Effects with cisplatin of Novel Palladium Complexes: DNA, BSA Interactions and Molecular Docking Study

Author(s): Nenad Joksimović, Nenad Janković, Jelena Petronijević, Dejan Baskić, Suzana Popovic, Danijela Todorović, Milan Zarić, Olivera Klisurić, Milan Vraneš, Aleksandar Tot and Zorica Bugarčić*
Pages: 1-14 (14)
Design and Synthesis of New Substituted Pyrazolopyridines with Potent Antiproliferative Activity

Author(s): Vassiliki Giannouli, Nikolaos Lougiakis, Ioannis K. Kostakis, Nicole Pouli*, Panagiotis Marakos, Alexios-Leandros Skaltsounis, David A. Horne, Sangkil Nam, Katerina Gioti and Roxane Tenta
Pages: 1-16 (16)
Chemistry, Alpha-glucosidase and Radical Scavenging Properties of Uranyl(VI) Hydrazide Complexes

Author(s): Parveen Akhter, Uzma Ashiq*, Rifat Ara Jamal, Zara Shaikh, Mohammad Mahroof-Tahir, Mehreen Lateef and Rooma Badar
Pages: 1-13 (13)
Target Based Virtual Screening of New Leads Inhibitor against Bacterial Cell Division Protein FtsZ for the Discovery of Antibacterial Agents

Author(s): Ratish Chandra Mishra, Rosy Kumari, Shivani Yadav and Jaya Parkash Yadav*
Pages: 1-7 (7)
Synthesis, Antimicrobial Evaluation and Molecular Docking of Some Potential 2,6-disubstituted 1H-Benzimidazoles; Non-Classical Antifolates

Author(s): Sunil Harer*, Manish Bhatia and Vikram Kawade
Pages: 1-20 (20)
Structure-activity Relationship Study on Therapeutically Relevant EGFR Double Mutant Inhibitors

Author(s): Shehnaz Fatima and Subhash Mohan Agarwal*
Pages: 1-10 (10)
The Effects of Trifluoromethylated Derivatives on Prostaglandin E2 and Thromboxane A2 Production in Human Leukemic U937 Macrophages

Author(s): Ivana Beara*, Tatjana Majkić, Stefania Fioravanti, Laura Trulli, Neda Mimica-Dukić, Lucio Pellacani and Luciano Saso
Pages: 1-6 (6)
Design, Synthesis, and Anti-bacterial Activity of Novel Deoxycholic Acid- Amino Alcohol Conjugates

Author(s): Satyendra Mishra* and Sejal Patel
Pages: 1-7 (7)
Polyethylene Glycol Acts as a Mechanistic Stabilizer of L-asparaginase: A Computational Probing

Author(s): R. Sindhu, H. Pradeep and H. K. Manonmani*
Pages: 1-9 (9)
Discovery and Optimization of a Series of Sulfonamide Inverse Agonists for the Retinoic Acid Receptor-related Receptor-α

Author(s): Christelle Doebelin, Yuanjun He, Sean Campbell, Philippe Nuhant, Naresh Kumar, Marcel Koenig, Ruben Garcia-Ordonez, Mi Ra Chang, William R. Roush, Li Lin, Susan Kahn, Michael D. Cameron, Patrick R. Griffin, Laura A. Solt* and Theodore M. Kamenecka*
Pages: 1-8 (8)
Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents

Author(s): Nikolaos Kollatos, Christos Mitsos, Stella Manta, Niki Tzioumaki, Christos Giannakas, Tania Alexouli, Aggeliki Panagiotopoulou, Dominique Schols, Graciela Andrei and Dimitri Komioti*
Pages: 1-17 (17)
Synthesis of New Hydrazone Derivatives and Evaluation of their Efficacy as Proliferation Inhibitors in Human Cancer Cells

Author(s): Piotr Świątek*, Jolanta Saczko, Nina Rembiałkowska and Julita Kulbacka
Pages: 1-8 (8)
Synthesis, Design and Antiplasmodial Evaluation of Sulfoximine-triazole Hybrids as Potential Antimalarial Prototypes

Author(s): Tommy Fredrick Mabasa, Awe Babatunde, Dustin Laming and Henok Hadgu Kinfe*
Pages: 1-8 (8)
Discovery of N-phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity

Author(s): Ahmed M. Abdelaziz, Sarah Diab, Saiful Islam, Sunita K. C. Basnet, Ben Noll, Peng Li, Laychiluh B. Mekonnen, Jingfeng Lu, Hugo Albrecht, Robert W. Milne, Cobus Gerber, Mingfeng Yu * and Shudong Wang*
Pages: 1-21 (21)
Synthesis, Plasmodium falciparum Inhibitory Activity, Cytotoxicity and Solubility of N2,N4-Disubstituted Quinazoline-2,4-diamines

Author(s): Nattakarn Pobsuk, Praphasri Suphakun, Supa Hannongbua, Chanin Nantasenamat, Kiattawee Choowongkomon and M. Paul Gleeson*
Pages: 1-12 (12)
Discovery of New Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors via Virtual Screening using Crystallography-derived Pharmacophore Modelling and QSAR Analysis

Author(s): Mahmoud A. Al-Sha`er*, Rua`a A. Al-Aqtash and Mutasem O. Taha
Pages: 1-14 (14)
Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus Strains

Author(s): A. Hilgeroth*, K. Yasrebi, S. Suzen, T. Hertlein, K. Ohlsen and M. Lalk
Pages: 1-7 (7)
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxypyrane- 4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors

Author(s): Hajar Sirous, Afshin Fassihi*, Simone Brogi*, Giuseppe Campiani, Frauke Christ, Zeger Debyser, Sandra Gemma, Stefania Butini, Giulia Chemi, Alessandro Grillo, Rezvan Zabihollahi, Mohammad R. Aghasadeghi, Lotfollah Saghaie and Hamid R. Memarian
Pages: 1-16 (16)
Benzoylthioureas: Design, Synthesis and Antimycobacterial Evaluation

Author(s): Tiago O. Brito, Lethícia O. Abreu, Karen M. Gomes, Maria C. S. Lourenço, Patricia M. L. Pereira, Sueli F. Yamada-Ogatta, Ângelo de Fàtima, Cesar A. Tisher, Fernando Macedo and Marcelle L. F. Bispo*
Pages: 1-11 (11)
Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors

Author(s): Barbara Cacciari*, Pamela Crepaldi, Chun Yan Cheng, Elena Bossi , Giampiero Spalluto, Stephanie Federico, Kenneth A. Jacobson and Marco Cattaneo
Pages: 1-10 (10)
The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents

Author(s): Edward Borowski, Natalia Salewska, Joanna Boros-Majewska, Marcin Serocki, Izabela Chabowska, Maria J. Milewska, Dominik Ziętkowski and Sławomir Milewski*
Pages: 1-12 (12)
New Quinazoline-Sulfonylurea Conjugates: Design, Synthesis and Hypoglycemic Activity

Author(s): Sahar M. Abou-Seri, AlShaimaa M. Taha, Mona A. Mohamed* and Nour M. Abdelkader
Pages: 1-14 (14)
Synthesis, Characterization, Antibacterial and Antioxidant Potency of NSubstituted- 2-Sulfanylidene-1,3-Thiazolidin-4-one Derivatives and QSAR Study

Author(s): Harshad Brahmbhatt, Maja Molnar*, Valentina Pavi and Vesna Rastijać
Pages: 1-10 (10)
Efficacy of Novel Schiff base Derivatives as Antifungal Compounds in Combination with Approved Drugs Against Candida Albicans

Author(s): Manzoor Ahmad Malik, Shabir Ahmad Lone, Parveez Gull, Ovas Ahmad Dar, Mohmmad Younus Wani, Aijaz Ahmad* and Athar Adil Hashmi*
Pages: 1-11 (11)
Evaluation of Cytotoxic Potentials of Some Isoindole-1, 3-Dione Derivatives on HeLa, C6 and A549 Cancer Cell Lines

Author(s): Ayse Tan, Ayse Sahin Yaglioglu, Nurhan Horasan Kishali*, Ertan Sahin and Yunus Kara*
Pages: 1-8 (8)
Design and Synthesis of Novel Sulfonamide-Derived Triazoles and Bioactivity Exploration

Author(s): Shi-Chao He, Hui-Zhen Zhang*, Hai-Juan Zhang, Qing Sun and Cheng-He Zhou
Pages: 1-14 (14)
Pyrrolopyrazoles: Synthesis, Evaluation and Pharmacological Screening as Antidepressant Agents

Author(s): Samar Said Fatahala*, Shahira Nofal, Eman Mahmoud and Rania Helmy Abd El-hameed
Pages: 1-12 (12)
Synthesis, Anti-Varicella-Zoster Virus and Anti-Cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles

Author(s): Wei-yuan Yuan, Xue Chen, Ning-ning Liu, Yi-ning Wen, Bei Yang, Graciela Andrei, Robert Snoeck, Yu-hong Xiang, Yong-wei Wu, Zhen Jiang, Dominique Schols, Zhuo-yong Zhang and Qin-pei Wu*
Pages: 1-12 (12)
Small Molecular Leads Differentially Active Against HER2 Positive and Triple Negative Breast Cancer Cell Lines

Author(s): Adnan Badran, Atia-tul-Wahab, Sharmeen Fayyaz, Elias Baydoun and M. Iqbal Choudhary*
Pages: 1-5 (5)
Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents

Author(s): Monika Gensicka-Kowalewska, Mirosława Cichorek, Anna Ronowska, Milena Deptuła, Ilona Klejbor and Krystyna Dzierzbicka*
Pages: 1-9 (9)
Evaluation of Antiplasmodial Potential of C-2 and C-8 Modified Quinolines: in vitro and in silico Study

Author(s): Rakesh Kumar, Ritika Sharma, Inder Kumar, Pooja Upadhyay, Ankit Kumar Dhiman, Rohit Kumar, Rakesh Kumar, Rituraj Purohit*, Dinkar Sahal* and Upendra Sharma*
Pages: 1-11 (11)
Synthesis and Biological Evaluation of Scutellarein Alkyl Derivatives as Preventing Neurodegenerative Agents with Improved Lipid Soluble Properties

Author(s): He-Min Li, Ting Gu, Wen-Yu Wu, Shao-Peng Yu, Tian-Yuan Fan, Yue Zhong and Nian-Guang Li*
Pages: 1-10 (10)
Design, Synthesis, Antimicrobial and Anti-biofilm Evaluation, and Molecular Docking of Newly Substituted Fluoroquinazolinones

Author(s): Mohamed F. Zayed, Sabrin R.M. Ibrahim*, EL-Sayed E. Habib, Memy H. Hassan, Sahar Ahmed and Heba S. Rateb
Pages: 1-17 (17)
Design, Synthesis, and Biological Evaluation of Novel Thiazolyl Substituted Bis-pyrazole Oxime Derivatives with Potent Antitumor Activities by Selectively Inducing Apoptosis and ROS in Cancer Cells

Author(s): Biao Xiong, Shi Chen, Peng Zhu, Meili Huang, Weijie Gao, Rui Zhu, Jianqiang Qian, Yanfu Peng, Yanan Zhang, Hong Dai and Yong Ling*
Pages: 1-12 (12)

E-Pub Full Text Articles

Novel Hybrids of Pyrazolidinedione and Benzothiazole as TZD Analogues. Rationale, Design, Synthesis and In Vivo Anti-Diabetic Evaluation

Advances in Structural Biology of ACE and Development of Domain Selective ACE-inhibitors

Synthesis, Biological Evaluation and Molecular Dynamics Simulation Studies of Novel Diphenyl Ethers

Bicycloheptylamine-Doxorubicin Conjugate: Synthesis and Anticancer Activities in σ2 Receptor-Expressing Cell Lines

New Copper Compounds with Antiplatelet Aggregation Activity

Design and Synthesis of New Sulfonamides–Based Flt3 Inhibitors

Cytotoxicity, Pro-apoptotic Activity and in silico Studies of Dithiocarbamates and their Structure Based Design and SAR Studies

Synthesis, Anticancer Evaluation and Synergistic Effects with cisplatin of Novel Palladium Complexes: DNA, BSA Interactions and Molecular Docking Study

Design and Synthesis of New Substituted Pyrazolopyridines with Potent Antiproliferative Activity

Chemistry, Alpha-glucosidase and Radical Scavenging Properties of Uranyl(VI) Hydrazide Complexes

Target Based Virtual Screening of New Leads Inhibitor against Bacterial Cell Division Protein FtsZ for the Discovery of Antibacterial Agents

Synthesis, Antimicrobial Evaluation and Molecular Docking of Some Potential 2,6-disubstituted 1H-Benzimidazoles; Non-Classical Antifolates

Structure-activity Relationship Study on Therapeutically Relevant EGFR Double Mutant Inhibitors

The Effects of Trifluoromethylated Derivatives on Prostaglandin E2 and Thromboxane A2 Production in Human Leukemic U937 Macrophages

Design, Synthesis, and Anti-bacterial Activity of Novel Deoxycholic Acid- Amino Alcohol Conjugates

Polyethylene Glycol Acts as a Mechanistic Stabilizer of L-asparaginase: A Computational Probing

Discovery and Optimization of a Series of Sulfonamide Inverse Agonists for the Retinoic Acid Receptor-related Receptor-α

Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents

Synthesis of New Hydrazone Derivatives and Evaluation of their Efficacy as Proliferation Inhibitors in Human Cancer Cells

Synthesis, Design and Antiplasmodial Evaluation of Sulfoximine-triazole Hybrids as Potential Antimalarial Prototypes

Discovery of N-phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity

Synthesis, Plasmodium falciparum Inhibitory Activity, Cytotoxicity and Solubility of N2,N4-Disubstituted Quinazoline-2,4-diamines

Discovery of New Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors via Virtual Screening using Crystallography-derived Pharmacophore Modelling and QSAR Analysis

Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus Strains

Synthesis, Molecular Modelling and Biological Studies of 3-hydroxypyrane- 4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors

Benzoylthioureas: Design, Synthesis and Antimycobacterial Evaluation

Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors

The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents

New Quinazoline-Sulfonylurea Conjugates: Design, Synthesis and Hypoglycemic Activity

Synthesis, Characterization, Antibacterial and Antioxidant Potency of NSubstituted- 2-Sulfanylidene-1,3-Thiazolidin-4-one Derivatives and QSAR Study

Efficacy of Novel Schiff base Derivatives as Antifungal Compounds in Combination with Approved Drugs Against Candida Albicans

Evaluation of Cytotoxic Potentials of Some Isoindole-1, 3-Dione Derivatives on HeLa, C6 and A549 Cancer Cell Lines

Design and Synthesis of Novel Sulfonamide-Derived Triazoles and Bioactivity Exploration

Pyrrolopyrazoles: Synthesis, Evaluation and Pharmacological Screening as Antidepressant Agents

Synthesis, Anti-Varicella-Zoster Virus and Anti-Cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles

Small Molecular Leads Differentially Active Against HER2 Positive and Triple Negative Breast Cancer Cell Lines

Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents

Evaluation of Antiplasmodial Potential of C-2 and C-8 Modified Quinolines: in vitro and in silico Study

Synthesis and Biological Evaluation of Scutellarein Alkyl Derivatives as Preventing Neurodegenerative Agents with Improved Lipid Soluble Properties

Design, Synthesis, Antimicrobial and Anti-biofilm Evaluation, and Molecular Docking of Newly Substituted Fluoroquinazolinones

Design, Synthesis, and Biological Evaluation of Novel Thiazolyl Substituted Bis-pyrazole Oxime Derivatives with Potent Antitumor Activities by Selectively Inducing Apoptosis and ROS in Cancer Cells