E-Pub Full Text Articles

Benzoin Schiff Bases: Design, Synthesis, and Biological Evaluation as Potential Antitumor Agents

Author(s): Dima A. Sabbah*, Fatima Al-Tarawneh, Wamidh H. Talib, Kamal Sweidan, Sanaa K. Bardaweel, Eveen Al-Shalabi, Haizhen A. Zhong, Ghassan Abu Sheikha, Reema Abu Khalaf and Mohammad S. Mubarak
Pages: 1-14 (14)
An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist

Author(s): Lena Trifonov, Michal Afri, Krzysztof Palczewski, Edward E. Korshin* and Arie Gruzman*
Pages: 1-7 (7)
Synthesis, cyclooxygenase-2 Inhibition, anti-inflammatory Evaluation and Docking Study of Substituted-N-(3,4,5-trimethoxyphenyl)-benzo[d]oxazole Derivatives

Author(s): Avneet Kaur*, Sharad Wakode , Dharam Pal Pathak, Vidushi Sharma and Ashok K Shakya
Pages: 1-14 (14)
Synthesis of a Novel Class of 1,3-oxathiolane Nucleoside Derivatives of T- 705 and Evaluation of Their Anti-influenza A Virus and Anti-HIV Activity

Author(s): Mingming Han, Xu Zhao, Xuedong Wu, Wei Huang, Xingzhou Li* and Fang Yu*
Pages: 1-9 (9)
Construction of an M1GS Ribozyme for Targeted and Rapid mRNA Cleavage; Application on the Ets-2 Oncogene

Author(s): Chrisavgi Toumpeki, Dimitrios Anastasakis, Ioannis Panagoulias, Vassiliki Stamatopoulou, Tassos Georgakopoulos, Sofia Kallia-Raftopoulos, Athanasia Mouzaki* and Denis Drainas*
Pages: 1-13 (13)
Towards the in-silico Design of New HSP90 Inhibitors: Molecular Docking and 3D-QSAR CoMFA Studies of Tetrahydropyrido [4, 3-d] Pyrimidine Derivatives as HSP90 Inhibitors

Author(s): Bakhtyar Sepehri* and Raouf Ghavami
Pages: 1-12 (12)
Synthesis of a Tyr-Tyr Dipeptide Library and Evaluation Against Tumor Cells

Author(s): Stanley NS Vasconcelos, Juliana M. Sciani, Nicole Mambeli Lisboa and Helio A Stefani*
Pages: 1-6 (6)
Anti-diabetic Phenolic Compounds of Black Carrot (Daucus carota Subspecies sativus var. atrorubens Alef.) Inhibit Enzymes of Glucose Metabolism: An in silico and in vitro Validation

Author(s): Suhas Gorakh Karkute, Tanmay Kumar Koley*, Bijen Kumar Yengkhom, Ajay Tripathi, Shivani Srivastava, Arti Maurya and Bijendra Singh
Pages: 1-9 (9)
Synthesis and Biological Evaluation of 12N-substituted Tricyclic Matrinic Derivatives as a Novel Family of Anti-Influenza Agents

Author(s): Sheng Tang, Yu-Huan Li , Xin–Yue Cheng, Jin–Qiu Yin , Ying–Hong Li , Dan–Qing Song , Yan–Xiang Wang * and Zhan–Dong Liu
Pages: 1-9 (9)
Emerging Roles of Purinergic Signaling in Diabetes

Author(s): Carmen Fotino, Diego Dal Ben and Elena Adinolfi*
Pages: 1-11 (11)
Design, Synthesis and Biological Evaluation of 7-arylbenzo[c]acridine-5,6- diones as Potential Anti-Leishmanial and anti-trypanosomal Agents

Author(s): Shivani Mahajan , Shabana Khan, Babu Tekwani , Ikhlas Khan and Inder Pal Singh*
Pages: 1-10 (10)
Activity of Diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside, its Hydrochloride, and N,N-dialkyl Derivatives Against Non-albicans Candida Isolates

Author(s): Malgorzata Anna Dawgul*, Daria Grzywacz, Beata Liberek, Wojciech Kamysz and Henryk Myszka
Pages: 1-8 (8)
Design and Synthesis of 3,4-diarylpyrrole Analogues as Potent Topoisomerase Inhibitors

Author(s): Qiang Zhao, Wang Chen*, Xu He, Zili Feng and Qi Liang
Pages: 1-10 (10)
Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line

Author(s): Salih Tuncay , Halil Senol, Eray Metin Guler , Nuket Ocal , Hasan Secen , Abdurrahim Kocyigit and Gulacti Topcu *
Pages: 1-9 (9)
Identification of New Chromenone Derivatives as Cholinesterase Inhibitors and Molecular Docking Studies

Author(s): Jamshed Iqbal *, Muhammad Shakeel Ahmad Abbasi, Sumera Zaib , Saifullah Afridi, Norbert Furtmann, Jurgen Bajorath and Peter Langer
Pages: 1-9 (9)
Synthesis and Structure-Activity Relationship; Exploration of Some Potent Anti-Cancer Phenyl Amidrazone Derivatives

Author(s): Almeqdad Y. Habashneh, Mustafa M. El-Abadelah, Sanaa K Bardaweel and Mutasem O. Taha*
Pages: 1-10 (10)
Xanthine Oxidase Inhibitory and Molecular Docking Studies on Pyrimidones

Author(s): Humaira Zafar, Sarosh Iqbal, Sumaira Javaid, Khalid M. Khan* and Muhammad I. Choudhary*
Pages: 1-12 (12)
Synthesis and Characterization of Thiocarbohydrazones and their Inhibitory Potential Against Ignored Disease Leishmaniasis

Author(s): Nida Ghouri*, Khalid Mohammed Khan, Arshia, M Iqbal Choudhary and Shahnaz Perveen
Pages: 1-8 (8)
New Bis-Pyrazolones as Potential Leads for ROS Inhibition; Environment Friendly Green Synthesis, Structural Characterization, and In Vitro Studies

Author(s): Sahar Yousuf*, Khalid Mohammed Khan, Uzma Salar, Almas Jabeen, Shakil Ahmed, Munira Taj Muhammad, Aisha Faheem and Shahnaz Perveen
Pages: 1-13 (13)
Facile Synthesis, Crystal Structure, DFT Calculation and Biological Activities of 4-(2-fluorophenyl)-3-(3-methoxybenzyl)-1H-1,2,4-triazol-5(4H)-one (5)

Author(s): Muhammad Saleem, Muhammad Rafiq, Yeon Ki Jeong, Dae Won Cho, Chong-Hyeak Kim, Sung-Yum Seo, Chang-Shik Choi, Seong-Karp Hong and Ki-Hwan Lee*
Pages: 1-9 (9)
Anti-Trypanosoma cruzi Activity in vitro of Phases and Isolated Compounds from Excoecaria lucida Leaves

Author(s): Cristiane Franca da Silva*, Ania Ochoa Pacheco, Rayane Nogueira Alves, Josean Fechine Tavares, Marcelo Sobral da Silva and Julio Cesar Escalona Arranz
Pages: 1-7 (7)
The Synthesis of Chalcones as Anticancer Prodrugs and their Bioactivation in CYP1 Expressing Breast Cancer Cells

Author(s): Ketan C Ruparelia*, Keti Zeka, Taeeba Ijaz, Dyan N. Ankrett, Nicola E. Wilsher, Paul C. Butler, Hoon L. Tan, Sabahat Lodhi, Avninder S. Bhambra, Gerard A. Potter, Randolph R Arroo and Kenneth J.M. Beresford
Pages: 1-11 (11)
Design, Synthesis, Evaluation and Computational Studies of Nipecotic Acid-Acetonaphthone Hybrids as Potential Antiepileptic Agents

Author(s): Ankit Seth, Piyoosh A. Sharma, Avanish Tripathi, Priyanka K. Choubey, Pavan Srivastava, Prabhash N Tripathi and Sushant Kumar Shrivastava*
Pages: 1-18 (18)
Synthesis of New Isoxazole-, Pyridazine-, Pyrimidopyrazines and Their Anti-Inflammatory and Analgesic Activity

Author(s): Ameen Ali Abu-Hashem* and Mohamed El-Shazly
Pages: 1-16 (16)
Prodrugs For Nitroreductase Based Cancer Therapy- 1 Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB

Author(s): Tugba Gungor, Gulden Yetis, Ferah Cömert Onder, Esra Tokay, Tugba Taşkın Tok, Ayhan Celik, Mehmet Ay* and Feray Kockar
Pages: 1-13 (13)
Synthesis and in vitro Antioxidant Activity Study of Some Novel Substituted Piperazinyl Flavone Compounds

Author(s): Elmas Sari, Paweł Berczynski, Aleksandra Kładna, Irena Kruk, Oya B Dundar, Monika Szymanska and Hassan Y. Aboul-Enein*
Pages: 1-15 (15)
Inhibition of Adipogenesis by Thiourea Derivatives

Author(s): Hina Siddiqui*, Sarah Shafi, Farah Mukhtar, Asma Ejaz, Atta-ur-Rahman and M. Iqbal Choudhary*
Pages: 1-8 (8)
Activity of Rifabutin and Hemi-synthetic Derivatives Against Mycobacterium abscessus

Author(s): Ivy B. Ramis*, Ricardo Figueiredo, Daniela F. Ramos, Priscila C.B. Halicki, Andrea von Groll, Miguel Viveiros, Maria do Ceu Costa and Pedro E.A. da Silva
Pages: 1-6 (6)
Antibacterial Assessment of Heteroaryl, Vinyl, Benzyl, and Alkyl Tetrazole Compounds

Author(s): Joshua Dudley, Liana Feinn, Heather DeFrancesco, Erica Lindsay, Adiel Coca* and Elizabeth Lewis Roberts
Pages: 1-6 (6)
A Novel Method to Synthesize Phosphocreatine and Phosphocreatine Prodrugs

Author(s): Maria Arkel, Patrizia Garbati, Annalisa Salis, Gianluca Damonte, Nara Liessi, Enrico Adriano, Umberto Benatti, Maurizio Balestrino and Enrico Millo*
Pages: 1-7 (7)
Synthesis, Cytotoxicity Evaluation, Molecular Docking and Utility of Novel Chalcones as Precursors for Heterocycles Incorporating Pyrazole Moiety

Author(s): Sobhi M. Gomha*, Magda A. Abdallah, Ikhlass M. Abbas and Mariam S.H. Kazem
Pages: 1-12 (12)
Anthranilic Acid Derivatives: Novel Inhibitors of Protein Glycation and the Associated Oxidative Stress in the Hepatocytes

Author(s): Humera Jahan*, Muhammad Iqbal Choudhary, Amber Atta, Khalid Mohammad Khan and Atta-ur- Rahman
Pages: 1-8 (8)
Design, Synthesis, and Evaluation of (2-(Pyridinyl)methylene)-1-tetralone Chalcones for Anticancer and Antimicrobial Activity

Author(s): Maya Z. Gibson, Minh A. Nguyen and Sarah K. Zingales*
Pages: 1-11 (11)
Efficient One-Pot Access to Trisubstituted 2-Benzazepin-3-ones as Constrained Pseudopeptide Analogues and Privileged Scaffolds

Author(s): Olivier Van der Poorten, Mouhamad Jida*, Dirk Tourwé and Steven Ballet
Pages: 1-9 (9)
Scaffold Hopping Strategy for the Design, Synthesis and Biological Activity Evaluation of Novel Hexacyclic Scutellarein Derivatives with a 1,3-Oxazine Ring Fused at A-ring

Author(s): Yue Zhong , Yu-Ting Lu, Ying Sun, Nian-Guang Li, Ting Gu, Wen-Yu Wu, Shao-Peng Yu and Zhi-Hao Shi *
Pages: 1-7 (7)

E-Pub Full Text Articles

Benzoin Schiff Bases: Design, Synthesis, and Biological Evaluation as Potential Antitumor Agents

An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist

Synthesis, cyclooxygenase-2 Inhibition, anti-inflammatory Evaluation and Docking Study of Substituted-N-(3,4,5-trimethoxyphenyl)-benzo[d]oxazole Derivatives

Synthesis of a Novel Class of 1,3-oxathiolane Nucleoside Derivatives of T- 705 and Evaluation of Their Anti-influenza A Virus and Anti-HIV Activity

Construction of an M1GS Ribozyme for Targeted and Rapid mRNA Cleavage; Application on the Ets-2 Oncogene

Towards the in-silico Design of New HSP90 Inhibitors: Molecular Docking and 3D-QSAR CoMFA Studies of Tetrahydropyrido [4, 3-d] Pyrimidine Derivatives as HSP90 Inhibitors

Synthesis of a Tyr-Tyr Dipeptide Library and Evaluation Against Tumor Cells

Anti-diabetic Phenolic Compounds of Black Carrot (Daucus carota Subspecies sativus var. atrorubens Alef.) Inhibit Enzymes of Glucose Metabolism: An in silico and in vitro Validation

Synthesis and Biological Evaluation of 12N-substituted Tricyclic Matrinic Derivatives as a Novel Family of Anti-Influenza Agents

Emerging Roles of Purinergic Signaling in Diabetes

Design, Synthesis and Biological Evaluation of 7-arylbenzo[c]acridine-5,6- diones as Potential Anti-Leishmanial and anti-trypanosomal Agents

Activity of Diosgenyl 2-amino-2-deoxy-β-D-glucopyranoside, its Hydrochloride, and N,N-dialkyl Derivatives Against Non-albicans Candida Isolates

Design and Synthesis of 3,4-diarylpyrrole Analogues as Potent Topoisomerase Inhibitors

Synthesis of Oleanolic Acid Analogues and Their Cytotoxic Effects on 3T3 Cell Line

Identification of New Chromenone Derivatives as Cholinesterase Inhibitors and Molecular Docking Studies

Synthesis and Structure-Activity Relationship; Exploration of Some Potent Anti-Cancer Phenyl Amidrazone Derivatives

Xanthine Oxidase Inhibitory and Molecular Docking Studies on Pyrimidones

Synthesis and Characterization of Thiocarbohydrazones and their Inhibitory Potential Against Ignored Disease Leishmaniasis

New Bis-Pyrazolones as Potential Leads for ROS Inhibition; Environment Friendly Green Synthesis, Structural Characterization, and In Vitro Studies

Facile Synthesis, Crystal Structure, DFT Calculation and Biological Activities of 4-(2-fluorophenyl)-3-(3-methoxybenzyl)-1H-1,2,4-triazol-5(4H)-one (5)

Anti-Trypanosoma cruzi Activity in vitro of Phases and Isolated Compounds from Excoecaria lucida Leaves

The Synthesis of Chalcones as Anticancer Prodrugs and their Bioactivation in CYP1 Expressing Breast Cancer Cells

Design, Synthesis, Evaluation and Computational Studies of Nipecotic Acid-Acetonaphthone Hybrids as Potential Antiepileptic Agents

Synthesis of New Isoxazole-, Pyridazine-, Pyrimidopyrazines and Their Anti-Inflammatory and Analgesic Activity

Prodrugs For Nitroreductase Based Cancer Therapy- 1 Metabolite Profile, Cell Cytotoxicity and Molecular Modeling Interactions of Nitro Benzamides with Ssap-NtrB

Synthesis and in vitro Antioxidant Activity Study of Some Novel Substituted Piperazinyl Flavone Compounds

Inhibition of Adipogenesis by Thiourea Derivatives

Activity of Rifabutin and Hemi-synthetic Derivatives Against Mycobacterium abscessus

Antibacterial Assessment of Heteroaryl, Vinyl, Benzyl, and Alkyl Tetrazole Compounds

A Novel Method to Synthesize Phosphocreatine and Phosphocreatine Prodrugs

Synthesis, Cytotoxicity Evaluation, Molecular Docking and Utility of Novel Chalcones as Precursors for Heterocycles Incorporating Pyrazole Moiety

Anthranilic Acid Derivatives: Novel Inhibitors of Protein Glycation and the Associated Oxidative Stress in the Hepatocytes

Design, Synthesis, and Evaluation of (2-(Pyridinyl)methylene)-1-tetralone Chalcones for Anticancer and Antimicrobial Activity

Efficient One-Pot Access to Trisubstituted 2-Benzazepin-3-ones as Constrained Pseudopeptide Analogues and Privileged Scaffolds

Scaffold Hopping Strategy for the Design, Synthesis and Biological Activity Evaluation of Novel Hexacyclic Scutellarein Derivatives with a 1,3-Oxazine Ring Fused at A-ring