E-Pub Full Text Articles

Discovery of N-phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity

Author(s): Ahmed M. Abdelaziz, Sarah Diab, Saiful Islam, Sunita K. C. Basnet, Ben Noll, Peng Li, Laychiluh B. Mekonnen, Jingfeng Lu, Hugo Albrecht, Robert W. Milne, Cobus Gerber, Mingfeng Yu * and Shudong Wang*
Pages: 1-21 (21)
pLoc_bal-mEuk: Predict Subcellular Localization of Eukaryotic Proteins by General PseAAC and Quasi-balancing Training Dataset

Author(s): Kuo-Chen Chou*, Xiang Cheng and Xuan Xiao
Pages: 1-14 (14)
Synthesis, Plasmodium falciparum Inhibitory Activity, Cytotoxicity and Solubility of N2,N4-Disubstituted Quinazoline-2,4-diamines

Author(s): Nattakarn Pobsuk, Praphasri Suphakun, Supa Hannongbua, Chanin Nantasenamat, Kiattawee Choowongkomon and M. Paul Gleeson*
Pages: 1-12 (12)
Discovery of New Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors via Virtual Screening using Crystallography-derived Pharmacophore Modelling and QSAR Analysis

Author(s): Mahmoud A. Al-Sha`er*, Rua`a A. Al-Aqtash and Mutasem O. Taha
Pages: 1-14 (14)
Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus Strains

Author(s): A. Hilgeroth*, K. Yasrebi, S. Suzen, T. Hertlein, K. Ohlsen and M. Lalk
Pages: 1-7 (7)
Synthesis, Molecular Modelling and Biological Studies of 3-hydroxypyrane- 4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors

Author(s): Hajar Sirous, Afshin Fassihi*, Simone Brogi*, Giuseppe Campiani, Frauke Christ, Zeger Debyser, Sandra Gemma, Stefania Butini, Giulia Chemi, Alessandro Grillo, Rezvan Zabihollahi, Mohammad R. Aghasadeghi, Lotfollah Saghaie and Hamid R. Memarian
Pages: 1-16 (16)
Benzoylthioureas: Design, Synthesis and Antimycobacterial Evaluation

Author(s): Tiago O. Brito, Lethícia O. Abreu, Karen M. Gomes, Maria C. S. Lourenço, Patricia M. L. Pereira, Sueli F. Yamada-Ogatta, Ângelo de Fàtima, Cesar A. Tisher, Fernando Macedo and Marcelle L. F. Bispo*
Pages: 1-11 (11)
Spirocyclohexadienones as an Uncommon Scaffold for Acetylcholinesterase Inhibitory Activity

Author(s): Ralph C. Gomes, Renata P. Sakata*, Wanda P. Almeida* and Fernando Coelho*
Pages: 1-10 (10)
Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors

Author(s): Barbara Cacciari*, Pamela Crepaldi, Chun Yan Cheng, Elena Bossi , Giampiero Spalluto, Stephanie Federico, Kenneth A. Jacobson and Marco Cattaneo
Pages: 1-10 (10)
The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents

Author(s): Edward Borowski, Natalia Salewska, Joanna Boros-Majewska, Marcin Serocki, Izabela Chabowska, Maria J. Milewska, Dominik Ziętkowski and Sławomir Milewski*
Pages: 1-12 (12)
New Quinazoline-Sulfonylurea Conjugates: Design, Synthesis and Hypoglycemic Activity

Author(s): Sahar M. Abou-Seri, AlShaimaa M. Taha, Mona A. Mohamed* and Nour M. Abdelkader
Pages: 1-14 (14)
Synthesis, Characterization, Antibacterial and Antioxidant Potency of NSubstituted- 2-Sulfanylidene-1,3-Thiazolidin-4-one Derivatives and QSAR Study

Author(s): Harshad Brahmbhatt, Maja Molnar*, Valentina Pavi and Vesna Rastijać
Pages: 1-10 (10)
Synthesis and Biological Studies of New Multifunctional Curcumin Platforms for Anticancer Drug Delivery

Author(s): Andrii Bazylevich , Helena Tuchinsky, Eti Zigman-Hoffman, Ran Weissman , Ofer Shpilberg , Oshrat Hershkovitz-Rokah, Leonid Patsenker and Gary Gellerman*
Pages: 1-12 (12)
Design, Synthesis and In Vitro Evaluation of Novel Anti-HIV 3-Pyrazol-3- yl-Pyridin-2-One Analogs

Author(s): Sanjay Kumar, Shiv Gupta, Shraddha Gaikwad, Leila Fotooh Abadi, Late Kamlesh Kumar Bhutani, Smita Kulkarni* and Inder Pal Singh*
Pages: 1-10 (10)
Efficacy of Novel Schiff base Derivatives as Antifungal Compounds in Combination with Approved Drugs Against Candida Albicans

Author(s): Manzoor Ahmad Malik, Shabir Ahmad Lone, Parveez Gull, Ovas Ahmad Dar, Mohmmad Younus Wani, Aijaz Ahmad* and Athar Adil Hashmi*
Pages: 1-11 (11)
The Inhibition of Polysialyltranseferase ST8SiaIV Through Heparin Binding to Polysialyltransferase Domain (PSTD)

Author(s): Li-Xin Peng, Xue-Hui Liu, Bo Lu, Si-Ming Liao, Feng Zhou, Ji-Min Huang, Dong Chen, Frederic A. Troy II, Guo-Ping Zhou* and Ri-Bo Huang*
Pages: 1-10 (10)
The Multiple Applications and Possible Mechanisms of the Hyperbaric Oxygenation Therapy

Author(s): Wan Chen, Xingmei Liang , Zhihuan Nong, Yaoxuan Li, Xiaorong Pan, Chunxia Chen * and Luying Huang*
Pages: 1-14 (14)
Structural Variability in the RLR-MAVS Pathway and Sensitive Detection of Viral RNAs

Author(s): Qiu-Xing Jiang *
Pages: 1-16 (16)
Inhibition of α-amylase Activity by Zn2⁺: Insights from Spectroscopy and Molecular Dynamics Simulations

Author(s): Si-Ming Liao, Nai-Kun Shen, Ge Liang, Bo Lu, Zhi-Long Lu, Li-Xin Peng, Feng Zhou, Li-Qin Du, Yu-Tuo Wei, Guo-Ping Zhou* and Ri-Bo Huang*
Pages: 1-11 (11)
pLoc_bal-mVirus: Predict Subcellular Localization of Multi-Label Virus Proteins by PseAAC and IHTS Treatment to Balance Training Dataset

Author(s): Xuan Xiao*, Xiang Cheng, Genqiang Chen, Qi Mao and Kuo-Chen Chou
Pages: 1-14 (14)
Evaluation of Cytotoxic Potentials of Some Isoindole-1, 3-Dione Derivatives on HeLa, C6 and A549 Cancer Cell Lines

Author(s): Ayse Tan, Ayse Sahin Yaglioglu, Nurhan Horasan Kishali*, Ertan Sahin and Yunus Kara*
Pages: 1-8 (8)
Design and Synthesis of Novel Sulfonamide-Derived Triazoles and Bioactivity Exploration

Author(s): Shi-Chao He, Hui-Zhen Zhang*, Hai-Juan Zhang, Qing Sun and Cheng-He Zhou
Pages: 1-14 (14)
Novel Conjugated Unsaturated Ketones with Submicromolar Potencies Towards some Leukemic and Colon Cancer Cells

Author(s): Swagatika Das, H. Inci Gul, Umashankar Das*, Jan Balzarini, Stephen G. Dimmock and Jonathan R. Dimmock *
Pages: 1-9 (9)
Design, Synthesis and Anxiolytic Activity Evaluation of N-Acyltryptophanyl- Containing Dipeptides, Potential TSPO Ligands

Author(s): T. A. Gudasheva, O. A. Deeva, G. V. Mokrov, A. S. Dyabina, M. A. Yarkova and S. B. Seredenin
Pages: 1-17 (17)
Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship

Author(s): Ana P. Bettencourt, Marian Castro, Joao P. Silva, Francisco Fernandes, Olga P. Coutinho, Maria J. Sousa, M. Fernanda Proenca* and Filipe M. Areias*
Pages: 1-11 (11)
Pyrrolopyrazoles: Synthesis, Evaluation and Pharmacological Screening as Antidepressant Agents

Author(s): Samar Said Fatahala*, Shahira Nofal, Eman Mahmoud and Rania Helmy Abd El-hameed
Pages: 1-12 (12)
Synthesis and Evaluation of Antifungal and Antitrypanosomastid Activities of Symmetrical 1,4-Disubstituted-1,2,3-Bistriazoles Obtained by CuAAC Conditions

Author(s): Mauricio M. Victor*, Ravir R. Farias, Danielle L. da Silva, Paulo Henrique Fonseca do Carmo, Maria A. de Resende-Stoianoff, Claudio Viegas, Patricia F. Espurie and Marcos J. Marquese
Pages: 1-9 (9)
Synthesis, Anti-Varicella-Zoster Virus and Anti-Cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles

Author(s): Wei-yuan Yuan, Xue Chen, Ning-ning Liu, Yi-ning Wen, Bei Yang, Graciela Andrei, Robert Snoeck, Yu-hong Xiang, Yong-wei Wu, Zhen Jiang, Dominique Schols, Zhuo-yong Zhang and Qin-pei Wu*
Pages: 1-12 (12)
Small Molecular Leads Differentially Active Against HER2 Positive and Triple Negative Breast Cancer Cell Lines

Author(s): Adnan Badran, Atia-tul-Wahab, Sharmeen Fayyaz, Elias Baydoun and M. Iqbal Choudhary*
Pages: 1-5 (5)
Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents

Author(s): Monika Gensicka-Kowalewska, Mirosława Cichorek, Anna Ronowska, Milena Deptuła, Ilona Klejbor and Krystyna Dzierzbicka*
Pages: 1-9 (9)
Evaluation of Antiplasmodial Potential of C-2 and C-8 Modified Quinolines: in vitro and in silico Study

Author(s): Rakesh Kumar, Ritika Sharma, Inder Kumar, Pooja Upadhyay, Ankit Kumar Dhiman, Rohit Kumar, Rakesh Kumar, Rituraj Purohit*, Dinkar Sahal* and Upendra Sharma*
Pages: 1-11 (11)
Synthesis and Biological Evaluation of Scutellarein Alkyl Derivatives as Preventing Neurodegenerative Agents with Improved Lipid Soluble Properties

Author(s): He-Min Li, Ting Gu, Wen-Yu Wu, Shao-Peng Yu, Tian-Yuan Fan, Yue Zhong and Nian-Guang Li*
Pages: 1-10 (10)
Design, Synthesis, Antimicrobial and Anti-biofilm Evaluation, and Molecular Docking of Newly Substituted Fluoroquinazolinones

Author(s): Mohamed F. Zayed, Sabrin R.M. Ibrahim*, EL-Sayed E. Habib, Memy H. Hassan, Sahar Ahmed and Heba S. Rateb
Pages: 1-17 (17)
Synthesis and Biological Evaluation of Polyfluoroalkylated Antipyrines and their Isomeric O-Methylpyrazoles

Author(s): Natalya Agafonova, Evgeny Shchegolkov*, Yanina Burgart, Victor Saloutin, Alexandra Trefilova, Galina Triandafilova, Sergey Solodnikov, Vera Maslova, Sophia Borisevich, Olga Krasnykh and Sergey Khursan
Pages: 1-16 (16)
Antiprotozoal Activities of Tetrazole-quinolines with Aminopiperidine Linker

Author(s): Patrick Hochegger, Johanna Faist, Werner Seebacher, Robert Saf, Pascal Mäser, Marcel Kaiser and Robert Weis*
Pages: 1-8 (8)
Rational Design of Colchicine Derivatives as anti-HIV Agents via QSAR and Molecular Docking

Author(s): Apilak Worachartcheewan*, Napat Songtawee, Suphakit Siriwong, Supaluk Prachayasittikul*, Chanin Nantasenamat and Virapong Prachayasittikul
Pages: 1-13 (13)
Ligand-Based Drug Design: Synthesis and Biological Evaluation of Substituted Benzoin Derivatives as Potential Antitumor Agents

Author(s): Dima A. Sabbah*, Ameerah Hasan Ibrahim, Wamidh H. Talib, Khalid M. Alqaisi, Kamal Sweidan, Sanaa K. Bardaweel, Ghassan Abu Sheikha, Haizhen A. Zhong, Eveen Al-Shalabi, Reema Abu Khalaf and Mohammad S. Mubarak
Pages: 1-13 (13)
New N,C-Diaryl-1,2,4-triazol-3-ones: Synthesis and Evaluation as Anticancer Agents

Author(s): Dolores Santa Maria*, Rosa M. Claramunt, Jose Elguero, Miguel Carda, Eva Falomir and Celia Martin-Beltran
Pages: 1-13 (13)
Anticancer Activity and Topoisomerase II Inhibition of Naphthalimides with ω-Hydroxylalkylamine Side-Chains of Different Lengths

Author(s): Mateusz D. Tomczyk, Anna Byczek Wyrostek, Klaudia Strama, Martyna Wawszków, Przemysław Kasprzycki and Krzysztof Z. Walczak*
Pages: 1-10 (10)
Antiproliferative Activity and Characterization of Metabolites of Aspergillus nidulans: An Endophytic Fungus from Nyctanthes arbor-tristis Linn. Against Three Human Cancer Cell Lines

Author(s): Talea Sana, Bina S. Siddiqui*, Saleem Shahzad, Ahsana D. Farooq, Faheema Siddiqui, Samia Sattar and Sabira Begum
Pages: 1-8 (8)
Design, Synthesis, and Biological Evaluation of Novel Thiazolyl Substituted Bis-pyrazole Oxime Derivatives with Potent Antitumor Activities by Selectively Inducing Apoptosis and ROS in Cancer Cells

Author(s): Biao Xiong, Shi Chen, Peng Zhu, Meili Huang, Weijie Gao, Rui Zhu, Jianqiang Qian, Yanfu Peng, Yanan Zhang, Hong Dai and Yong Ling*
Pages: 1-12 (12)

E-Pub Full Text Articles

Discovery of N-phenyl-4-(1H-pyrrol-3-yl)pyrimidin-2-amine Derivatives as Potent Mnk2 Inhibitors: Design, Synthesis, SAR Analysis, and Evaluation of in vitro Anti-leukaemic Activity

pLoc_bal-mEuk: Predict Subcellular Localization of Eukaryotic Proteins by General PseAAC and Quasi-balancing Training Dataset

Synthesis, Plasmodium falciparum Inhibitory Activity, Cytotoxicity and Solubility of N2,N4-Disubstituted Quinazoline-2,4-diamines

Discovery of New Phosphoinositide 3-kinase Delta (PI3Kδ) Inhibitors via Virtual Screening using Crystallography-derived Pharmacophore Modelling and QSAR Analysis

Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus Strains

Synthesis, Molecular Modelling and Biological Studies of 3-hydroxypyrane- 4-one and 3-hydroxy-pyridine-4-one Derivatives as HIV-1 Integrase Inhibitors

Benzoylthioureas: Design, Synthesis and Antimycobacterial Evaluation

Spirocyclohexadienones as an Uncommon Scaffold for Acetylcholinesterase Inhibitory Activity

Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors

The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents

New Quinazoline-Sulfonylurea Conjugates: Design, Synthesis and Hypoglycemic Activity

Synthesis, Characterization, Antibacterial and Antioxidant Potency of NSubstituted- 2-Sulfanylidene-1,3-Thiazolidin-4-one Derivatives and QSAR Study

Synthesis and Biological Studies of New Multifunctional Curcumin Platforms for Anticancer Drug Delivery

Design, Synthesis and In Vitro Evaluation of Novel Anti-HIV 3-Pyrazol-3- yl-Pyridin-2-One Analogs

Efficacy of Novel Schiff base Derivatives as Antifungal Compounds in Combination with Approved Drugs Against Candida Albicans

The Inhibition of Polysialyltranseferase ST8SiaIV Through Heparin Binding to Polysialyltransferase Domain (PSTD)

The Multiple Applications and Possible Mechanisms of the Hyperbaric Oxygenation Therapy

Structural Variability in the RLR-MAVS Pathway and Sensitive Detection of Viral RNAs

Inhibition of α-amylase Activity by Zn2+: Insights from Spectroscopy and Molecular Dynamics Simulations

pLoc_bal-mVirus: Predict Subcellular Localization of Multi-Label Virus Proteins by PseAAC and IHTS Treatment to Balance Training Dataset

Evaluation of Cytotoxic Potentials of Some Isoindole-1, 3-Dione Derivatives on HeLa, C6 and A549 Cancer Cell Lines

Design and Synthesis of Novel Sulfonamide-Derived Triazoles and Bioactivity Exploration

Novel Conjugated Unsaturated Ketones with Submicromolar Potencies Towards some Leukemic and Colon Cancer Cells

Design, Synthesis and Anxiolytic Activity Evaluation of N-Acyltryptophanyl- Containing Dipeptides, Potential TSPO Ligands

Phenolic Imidazole Derivatives with Dual Antioxidant/Antifungal Activity: Synthesis and Structure-Activity Relationship

Pyrrolopyrazoles: Synthesis, Evaluation and Pharmacological Screening as Antidepressant Agents

Synthesis and Evaluation of Antifungal and Antitrypanosomastid Activities of Symmetrical 1,4-Disubstituted-1,2,3-Bistriazoles Obtained by CuAAC Conditions

Synthesis, Anti-Varicella-Zoster Virus and Anti-Cytomegalovirus Activity of 4,5-Disubstituted 1,2,3-(1H)-Triazoles

Small Molecular Leads Differentially Active Against HER2 Positive and Triple Negative Breast Cancer Cell Lines

Synthesis and Biological Evaluation of Acridine/Acridone Analogs as Potential Anticancer Agents

Evaluation of Antiplasmodial Potential of C-2 and C-8 Modified Quinolines: in vitro and in silico Study

Synthesis and Biological Evaluation of Scutellarein Alkyl Derivatives as Preventing Neurodegenerative Agents with Improved Lipid Soluble Properties

Design, Synthesis, Antimicrobial and Anti-biofilm Evaluation, and Molecular Docking of Newly Substituted Fluoroquinazolinones

Synthesis and Biological Evaluation of Polyfluoroalkylated Antipyrines and their Isomeric O-Methylpyrazoles

Antiprotozoal Activities of Tetrazole-quinolines with Aminopiperidine Linker

Rational Design of Colchicine Derivatives as anti-HIV Agents via QSAR and Molecular Docking

Ligand-Based Drug Design: Synthesis and Biological Evaluation of Substituted Benzoin Derivatives as Potential Antitumor Agents

New N,C-Diaryl-1,2,4-triazol-3-ones: Synthesis and Evaluation as Anticancer Agents

Anticancer Activity and Topoisomerase II Inhibition of Naphthalimides with ω-Hydroxylalkylamine Side-Chains of Different Lengths

Antiproliferative Activity and Characterization of Metabolites of Aspergillus nidulans: An Endophytic Fungus from Nyctanthes arbor-tristis Linn. Against Three Human Cancer Cell Lines

Design, Synthesis, and Biological Evaluation of Novel Thiazolyl Substituted Bis-pyrazole Oxime Derivatives with Potent Antitumor Activities by Selectively Inducing Apoptosis and ROS in Cancer Cells

Inhibition of α-amylase Activity by Zn2⁺: Insights from Spectroscopy and Molecular Dynamics Simulations