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Pyrazoles and Fused Pyrimidines: Synthesis, Structure Elucidation, Antitubercular Activity and Molecular Docking Study

Author(s): Amerah M. Al-Soliemy, Rehab Sabour and Thoraya A. Farghaly*
Pages: 1-18 (18)
Coumarins and Quinolones as Effective Multiple Targeted Agents Versus Covid-19: An In silico Study

Author(s): Mojgan Nejabat, Razieh Ghodsi and Farzin Hadizadeh*
Pages: 1-18 (18)
Piroxicam Analogs: Design, Synthesis, Docking Study and Biological Evaluation as Promising Anti-HIV-1 agents

Author(s): Ali Imani, Sepehr Soleymani, Rouhollah Vahabpour, Zahra Hajimahdi* and Afshin Zarghi*
Pages: 1-11 (11)
Synthesis, Biological Profile, and Molecular Docking of Some New Bis- Imidazole Fused Templates and Investigation of Their Cytotoxic Potential as Anti-tubercular and/or Anticancer Prototypes

Author(s): Refaie M. Kassab, Sobhi M. Gomha, Zeinab A. Muhammad* and Ahmed S. El-khouly
Pages: 1-12 (12)
Chalcones as Scavengers of HOCl and Inhibitors of Oxidative Burst: Structure-Activity Relationship Studies

Author(s): Thaise Martins, Vera L.M. Silva, Artur M.S. Silva, José L.F.C. Lima, Eduarda Fernandes* and Daniela Ribeiro*
Pages: 1-9 (9)
Synthesis, Cytotoxicity, Anti-migration and Anti-Invasion Activity of Diphyllin Heterocyclic Derivatives

Author(s): Weidong Shen, Haijiao Chen, Miaomiao Wu, Ting Zhang, Li Zhu and Yu Zhao*
Pages: 1-8 (8)
Synthesis, Molecular Docking, BSA, and In-Vitro Reactivation Study of Imidazopyridine Oximes Against Paraoxon Inhibited Acetylcholinesterase

Author(s): Ashima Thakur, Jayant Patwa, Abha Sharma* and Swaran Jeet Singh Flora
Pages: 1-15 (15)
Synthesis and Biological Evaluation of 4-Aminoantipyrine Analogues

Author(s): Houwei Ren, Premnath Dhanaraj, Israel V M V Enoch*, Mosae Selvakumar Paulraj and Indiraleka M
Pages: 1-10 (10)
Synthesis and Clinical Development of Palbociclib: An overview

Author(s): Debabrata Konar, Saurabh Maru, Subhabrata Kar and Kapil Kumar*
Pages: 1-24 (24)
Synthesis and Evaluation of Cytotoxicity of Novel Coumarin Peptide Alcohol Derivatives

Author(s): Digamber S. Pawar, Vasant V. Chabukswar*, Savita R. Tapase, Kisan M. Kodam, Anurudhha Chabukswar, Pravin B. Adhav, Balasaheb B. Diwate, Sunita Salunke Gawali, Sabrina Dallavalle and Swati C. Jagdale
Pages: 1-11 (11)
2, 4, 5-Trideoxyhexopyranosides Derivatives of 4’-Demethylepipodophyllotoxin: De novo Synthesis and Anticancer Activity

Author(s): Yapeng Lu, Li Zhu, Rui Cai, Yu Li and Yu Zhao*
Pages: 1-10 (10)
Design, Synthesis, and Pharmacokinetic Evaluation of O-Carbamoyl Tizoxanide Prodrugs

Author(s): Xi He, Wenjun Hu, Fanhua Meng and Xingzhou Li*
Pages: 1-11 (11)
Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and downregulation of c-Myc

Author(s): Raül Agut, Eva Falomir*, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda, J. Fernando Díaz, Fernando Josa-Prado and J. Alberto Marco
Pages: 1-11 (11)
Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

Author(s): Vitor F. Ferreira, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G. S. Lima and Fernando de C. da Silva*
Pages: 1-13 (13)
Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents

Author(s): Haicheng Liu, Yushi Futamura, Honghai Wu, Aki Ishiyama, Taotao Zhang, Tao Shi, Qunxiong Zheng, Masato Iwatsuki, Satoshi Ōmura, Hongbin Zou* and Hiroyuki Osada*
Pages: 1-12 (12)
Computational Study and Synthesis of a New Class of Anticonvulsants with 6 Hz Psychomotor Seizure Test Activity: 2-(1,3-benzodioxol-5-yloxy)- N'-[substituted]-acetohydrazides

Author(s): Praveen Kumar* and Laxmi Tripathi
Pages: 1-18 (18)
Exploring the Selectivity Profile of Sigma Receptor Ligands by Molecular Docking and Pharmacophore Analyses

Author(s): Giada Righetti, Michele Tonelli, Paola Fossa and Elena Cichero*
Pages: 1-15 (15)
Anti-oxidant and Antiproliferative Activities of Mongolian Medicinal Plant Extracts and Structure Isolation of Gnetin - H Compound

Author(s): Altannavch Nyamsambuu, Ashfaque Ahmed, Farjana Yeasmin Khusbu, Sarangerel Oidovsambuu, Md. Asaduzzaman Khan, Xi Zhou, Jun-jiang Fu and Han-Chun Chen*
Pages: 1-11 (11)
Multi-target Directed Compounds with Antioxidant and/or Antiinflammatory Properties as Potent Agents for Alzheimer’s Disease

Author(s): Papagiouvannis Georgios*, Theodosis-Nobelos Panagiotis, Kourounakis N. Panos and Rekka A. Eleni
Pages: 1-18 (18)
Antidiabetic and Antioxidative Properties of Novel Zn(II)-cinnamic Acid Complex

Author(s): Chika I. Chukwuma*, Samson S. Mashele and Shasank S. Swain
Pages: 1-13 (13)
Voltage-Dependent Sodium Channel Blocker Anticonvulsants: An Approach to the Structure-Activity Relationship

Author(s): M. del Carmen Salazar-López, J. Alberto Guevara-Salazar*, Mónica G. Arellano-Mendoza, Hugo A. Jiménez-Vázquez, Adriana Benavides and Delia Quintana-Zavala
Pages: 1-23 (23)
Design and Synthesis of Novel Anti-inflammatory/Anti-ulcer Hybrid Molecules with Antioxidant Activity

Author(s): Bhim Bahadur Chaudhari, Alka Bali* and Ajitesh Balaini
Pages: 1-13 (13)
A New Series of Triazolothiadiazines as Potential Anticancer Agents for Targeted Therapy of Non-small Cell Lung and Colorectal Cancers: Design, Synthesis, In silico and In vitro Studies Providing Mechanistic Insight into their Anticancer Potencies

Author(s): Belgin Sever, Mehlika Dilek Altıntop*, Gülşen Akalın Çiftçi and Ahmet Özdemir
Pages: 1-25 (25)
Chemical IN04 Inhibits the Kinase Domain not the ROC Domain of LRRK1: Results from Homology Modeling and Molecular Docking

Author(s): Zhenhang Chen, Weirong Xing and Li Fan*
Pages: 1-11 (11)
Synthesis, Biological Evaluation, and QPLD Studies of Piperazine Derivatives as Potential DPP-IV Inhibitors

Author(s): Reema Abu Khalaf*, Haya Abu Jarad, Tariq Al-Qirim and Dima Sabbah
Pages: 1-8 (8)
Synthesis, Characterization and Biological Studies of Organoselenium trans-Palladium(II) Complexes

Author(s): Ivana Raković, Jovana Bogojeski*, Katarina Mladenović, Angelina Petrović, Vera Divac, Kristina Mihailović, Biljana Popovska Jovicić, Marina Kostić, Predrag Canović, Nevena Milivojević, Marko Zivanović and Ivana Radojević
Pages: 1-16 (16)
Novel 4-Oxo-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylic Acid Derivatives as HIV-1 Integrase Inhibitors: Synthesis, Docking Studies, Molecular Dynamics Simulation and Biological Activities

Author(s): Elnaz Ebrahim Zadeh, Rouhollah Vahabpour, Amirreza Dowlati Beirami, Zahra Hajimahdi and Afshin Zarghi*
Pages: 1-12 (12)
Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer

Author(s): Jamshed Iqbal*, Ayesha Basharat, Sehrish Bano, Syed Mobasher Ali Abid, Julie Pelletier and Jean Sévigny
Pages: 1-9 (9)
Design, Synthesis, and Anti-Neuroinflammatory Activity of Amide- Containing Dithiolethiones

Author(s): Karrington Craig, Paula Avila and Dennis A. Brown*
Pages: 1-9 (9)
Evaluation of Ligustrazine-Based Synthetic Compounds for their Antiproliferative Effects

Author(s): Syed Nasir Abbas Bukhari*, Nasser Hadal Alotaibi, Waqas Ahmad, Khalid Saad Alharbi, Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Muhammad Masood Ahmad, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja and Muhammad Ajaz Hussain
Pages: 1-7 (7)
Oreganum Vulgare: In-vitro Assessment of Cytotoxicity, Molecular Docking Studies, Antioxidant and Anti-inflammatory Activity in LPS Stimulated RAW 264.7 Cells

Author(s): Reyaz Hassan Mir, Gifty Sawhney, Rohini Verma, Bilal Ahmad, Parveen Kumar, Soni Ranjana, Asha Bhagat, Sreedhar Madishetti, Zabeer Ahmed, Sanjay M Jachak, Sangdun Choi and Mubashir Hussain Masoodi*
Pages: 1-11 (11)
Synthesis and in vitro anti-HCV and Antitumor Evaluation of Schisandronic Acid Derivatives

Author(s): Kai-Xia Zhang, Xi-Jing Qian, Wei-Zheng, Meng-Cheng Cai, Ying Ma, Da-Zhi Zhang, Shi-Chong Yu, Qing-Guo Meng and Yong-Sheng Jin*
Pages: 1-9 (9)
Indane-1,3-diones: As Potential and Selective α-glucosidase Inhibitors, their Synthesis, in vitro and in silico Studies

Author(s): Asma Mukhtar, Shazia Shah, Kanwal, Shehryar Hameed, Khalid Mohammed Khan*, Shahid Ullah Khan, Sumera Zaib, Jamshed Iqbal and Shahnaz Parveen
Pages: 1-16 (16)
Synthesis and Structure-Activity Relationshπip Studies of N-monosubstituted Aroylthioureas as Urease Inhibitors

Author(s): Wei-Wei Ni, Hai-Lian Fang, Ya-Xi Ye, Wei-Yi Li, Li Liu, Zi-Juan Fu, Dawalamu, Wen-Yan Zhu, Ke Li, Fang Li, Xia Zou, Hui Ouyang, Zhu-Ping Xiao and Hai-Liang Zhu*
Pages: 1-14 (14)
Natural Naphthoquinones Naphthoquinone-based Hydrazone Hybrids: Synthesis and Potent Activity Against Cancer Cell Lines

Author(s): Délis Galvão Guimarães, Arlan de Assis Gonsalves, Larissa Araújo Rolim, Edigênia Cavalcante Araújo, Victória Laysna dos Anjos Santos, Maria Francilene Souza Silva, Fátima de Cássia Evangelista de Oliveira, Marcília Pinheiro da Costa, Claudia Pessoa, Marília Oliveira Fonseca Goulart, Thaissa Lucio Silva, Danyelle Cândido Santos and Cleônia Roberta Melo Araújo*
Pages: 1-11 (11)
Chalcones: As Potent α-amylase Enzyme Inhibitors; Synthesis, In Vitro, and In Silico Studies

Author(s): Mahboob Ali, Momin Khan, Khair Zaman, Abdul Wadood, Maryam Iqbal, Aftab Alam, Sana Shah, Ashfaq Ur Rehman, Muhammad Yousaf, Rafaila Rafique and Khalid Mohammed Khan*
Pages: 1-10 (10)
Design and Synthesis of Arylnaphthalene Lignan Lactone Derivatives as Potent Topoisomerase Inhibitors

Author(s): Wang Chen, Zili Feng*, Daihua Hu and Jin Meng
Pages: 1-10 (10)
Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies

Author(s): Taibi Ben Hadda, Fatma Sezer Senol Deniz, Ilkay Erdogan Orhan, Hsaine Zgou, Abdur Rauf, Yahia Nasser Mabkhot, Brahim Bennani, Dalia R. Emam, Nabila Abdelshafy Kheder, Abdulrhman Asayari, Abdullatif Bin Muhsinah and Aneela Maalik*
Pages: 1-10 (10)
Synthesis of Novel 1,2,3-Triazole Derivatives of Isocoumarins and 3,4- Dihydroisocoumarin with Potential Antiplasmodial Activity In Vitro

Author(s): Lucas da Silva Santos, Matheus Fillipe Langanke de Carvalho, Ana Claudia de Souza Pinto, Amanda Luisa da Fonseca, Julio César Dias Lopes, Fernando de Pilla Varotti, Rossimiriam Pereira de Freitas and Rosemeire Brondi Alves*
Pages: 1-14 (14)
Pyrazole Derivatives of Medically Relevant Phenolic Acids: Insight into Antioxidative and Anti-LOX Activity

Author(s): Vesna Milovanović, Zorica D. Petrović*, Slađana Novaković, Goran A. Bogdanović, Dušica Simijonović, Milan Mladenović, Jovica Branković and Vladimir P. Petrović
Pages: 1-13 (13)
Withdrawal Notice: The Design, Synthesis, Pharmacokinetic and Pharmacodynamic Evaluation of Acyloxyalkyl-substituted T705 Prodrugs

Author(s): Xingzhou Li, Tianhong Zhang and Wu Zhong
Pages: 1-1 (1)

E-Pub Full Text Articles

Pyrazoles and Fused Pyrimidines: Synthesis, Structure Elucidation, Antitubercular Activity and Molecular Docking Study

Coumarins and Quinolones as Effective Multiple Targeted Agents Versus Covid-19: An In silico Study

Piroxicam Analogs: Design, Synthesis, Docking Study and Biological Evaluation as Promising Anti-HIV-1 agents

Synthesis, Biological Profile, and Molecular Docking of Some New Bis- Imidazole Fused Templates and Investigation of Their Cytotoxic Potential as Anti-tubercular and/or Anticancer Prototypes

Chalcones as Scavengers of HOCl and Inhibitors of Oxidative Burst: Structure-Activity Relationship Studies

Synthesis, Cytotoxicity, Anti-migration and Anti-Invasion Activity of Diphyllin Heterocyclic Derivatives

Synthesis, Molecular Docking, BSA, and In-Vitro Reactivation Study of Imidazopyridine Oximes Against Paraoxon Inhibited Acetylcholinesterase

Synthesis and Biological Evaluation of 4-Aminoantipyrine Analogues

Synthesis and Clinical Development of Palbociclib: An overview

Synthesis and Evaluation of Cytotoxicity of Novel Coumarin Peptide Alcohol Derivatives

2, 4, 5-Trideoxyhexopyranosides Derivatives of 4’-Demethylepipodophyllotoxin: De novo Synthesis and Anticancer Activity

Design, Synthesis, and Pharmacokinetic Evaluation of O-Carbamoyl Tizoxanide Prodrugs

Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and downregulation of c-Myc

Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents

Computational Study and Synthesis of a New Class of Anticonvulsants with 6 Hz Psychomotor Seizure Test Activity: 2-(1,3-benzodioxol-5-yloxy)- N'-[substituted]-acetohydrazides

Exploring the Selectivity Profile of Sigma Receptor Ligands by Molecular Docking and Pharmacophore Analyses

Anti-oxidant and Antiproliferative Activities of Mongolian Medicinal Plant Extracts and Structure Isolation of Gnetin - H Compound

Multi-target Directed Compounds with Antioxidant and/or Antiinflammatory Properties as Potent Agents for Alzheimer’s Disease

Antidiabetic and Antioxidative Properties of Novel Zn(II)-cinnamic Acid Complex

Voltage-Dependent Sodium Channel Blocker Anticonvulsants: An Approach to the Structure-Activity Relationship

Design and Synthesis of Novel Anti-inflammatory/Anti-ulcer Hybrid Molecules with Antioxidant Activity

A New Series of Triazolothiadiazines as Potential Anticancer Agents for Targeted Therapy of Non-small Cell Lung and Colorectal Cancers: Design, Synthesis, In silico and In vitro Studies Providing Mechanistic Insight into their Anticancer Potencies

Chemical IN04 Inhibits the Kinase Domain not the ROC Domain of LRRK1: Results from Homology Modeling and Molecular Docking

Synthesis, Biological Evaluation, and QPLD Studies of Piperazine Derivatives as Potential DPP-IV Inhibitors

Synthesis, Characterization and Biological Studies of Organoselenium trans-Palladium(II) Complexes

Novel 4-Oxo-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylic Acid Derivatives as HIV-1 Integrase Inhibitors: Synthesis, Docking Studies, Molecular Dynamics Simulation and Biological Activities

Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer

Design, Synthesis, and Anti-Neuroinflammatory Activity of Amide- Containing Dithiolethiones

Evaluation of Ligustrazine-Based Synthetic Compounds for their Antiproliferative Effects

Oreganum Vulgare: In-vitro Assessment of Cytotoxicity, Molecular Docking Studies, Antioxidant and Anti-inflammatory Activity in LPS Stimulated RAW 264.7 Cells

Synthesis and in vitro anti-HCV and Antitumor Evaluation of Schisandronic Acid Derivatives

Indane-1,3-diones: As Potential and Selective α-glucosidase Inhibitors, their Synthesis, in vitro and in silico Studies

Synthesis and Structure-Activity Relationshπip Studies of N-monosubstituted Aroylthioureas as Urease Inhibitors

Natural Naphthoquinones Naphthoquinone-based Hydrazone Hybrids: Synthesis and Potent Activity Against Cancer Cell Lines

Chalcones: As Potent α-amylase Enzyme Inhibitors; Synthesis, In Vitro, and In Silico Studies

Design and Synthesis of Arylnaphthalene Lignan Lactone Derivatives as Potent Topoisomerase Inhibitors

Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies

Synthesis of Novel 1,2,3-Triazole Derivatives of Isocoumarins and 3,4- Dihydroisocoumarin with Potential Antiplasmodial Activity In Vitro

Pyrazole Derivatives of Medically Relevant Phenolic Acids: Insight into Antioxidative and Anti-LOX Activity

Withdrawal Notice: The Design, Synthesis, Pharmacokinetic and Pharmacodynamic Evaluation of Acyloxyalkyl-substituted T705 Prodrugs