E-Pub Full Text Articles

Novel p-Functionalized Chromen-4-on-3-yl Chalcones Bearing Astonishing Boronic Acid Moiety as MDM2 Inhibitor: Synthesis, Cytotoxic Evaluation and Simulation Studies

Author(s): Richa Kaur Bhatia*, Lakhwinder Singh, Ruchika Garg, Maninder Kaur, Manmohan Yadav, Jitender Madan, Satyavathi Kancherla, Raghuvir R. S. Pissurlenkar and Evans C. Coutinho
Pages: 1-17 (17)
Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates

Author(s): Mayara Salles Souza do Nascimento, Vitória Regina Fontes Câmara, Juliana Silva da Costa, Juliana M. Chaves Barbosa, Alessandra Silva Maia Lins, Kelly Salomão, Solange Lisboa de Castro, Samir Aquino Carvalho, Edson Ferreira da Silva and Carlos Alberto Manssour Fraga*
Pages: 1-10 (10)
Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (type II)

Author(s): Özgür Yılmaz, Burak Bayer, Hatice Bekçi, Abdullah Ibrahim Uba, Ahmet Cumaoğlu, Kemal Yelekçi and Ş. Güniz Küçükgüzel*
Pages: 1-15 (15)
Cyclic Tripeptide-based Potent and Selective Human SIRT5 Inhibitors

Author(s): Yanhong Jiang and Weiping Zheng*
Pages: 1-10 (10)
Synthesis and Evaluation of Glycyrrhetic Acid-aromatic Hybrids as Antiinflammatory Agents

Author(s): Zhi Chen, Shi-Chao Chen, Bo Li, Yong-An Yang and Jing Zhang*
Pages: 1-8 (8)
Design, Synthesis and Evaluation of 8-Thiosubstituted 1,3,7- Trimethylxanthine Hydrazones with In Vitro Neuroprotective and MAO-B Inhibitory Activities

Author(s): Javor Mitkov, Alexandra Kasabova-Angelova, Magdalena Kondeva-Burdina, Virginia Tzankova, Diana Tzankova, Maya Georgieva and Alexander Zlatkova*
Pages: 1-14 (14)
Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana

Author(s): Krisnna Mariana Aranda Alves, Fábio José Bonfim Cardoso, Kathia Maria Honorio and Fábio Alberto de Molfetta*
Pages: 1-12 (12)
Styrylquinoline – A Versatile Scaffold in Medicinal Chemistry

Author(s): Robert Musiol*
Pages: 1-14 (14)
Synthesis of N-Substituted Benzamide Derivatives and their Evaluation as Antitumor Agents

Author(s): Taiping Chen, Hongwu Jiang, Jianjun Zhou, Zicheng Li*, Wencai Huang, Youfu Luo and Yinglan Zhao
Pages: 1-8 (8)
Synthesis, Characterization, Antimicrobial Activity and Anticancer of Some New pyrazolo[1,5-a]pyrimidines and pyrazolo[5,1-c]1,2,4-triazines

Author(s): Mona A. Hosny, Yasser H. Zaki*, Wafaa A. Mokbel and Abdou O Abdelhamid
Pages: 1-11 (11)
Thiazole Compounds as Antiviral Agents: An Update

Author(s): Inder Pal Singh*, Shiv Gupta and Sanjay Kumar
Pages: 1-20 (20)
Molecular Docking and Dynamics Simulation Analysis of Thymoquinone and Thymol Compounds from Nigella Sativa L. that Inhibits P38 Protein: Probable Remedies for Hepatocellular Carcinoma

Author(s): Heena Tabassum and Iffat Zareen Ahmad*
Pages: 1-8 (8)
Synthesis of β-Ketosulfone Derivatives As New Non-Cytotoxic Urease Inhibitors In Vitro

Author(s): Sarosh Iqbal*, Ajmal Khan, Rashid Nazir, Shumaila Kiran, Shahnaz Perveen, Khalid Mohammed Khan* and M. Iqbal Choudhary*
Pages: 1-12 (12)
Matrine-Family Alkaloids: Versatile Precursors for Bioactive Modifications

Author(s): Xiao-hua Cai*, Hong-yan Zhang and Bing Xie*
Pages: 1-24 (24)
Design, Synthesis and Biological Evaluation of Anti-tuberculosis Agents based on Bedaquiline Structure

Author(s): Chengjun Wu*, Jinghan Luo, Mengtong Wu, Fanzhen Meng, Zhiqiang Cai, Yu Chen and Tiemin Sun
Pages: 1-12 (12)
Three Dimensional Quantitative Structure Activity Relationship and Pharmacophore Modeling of Tacrine Derivatives as Acetylcholinesterase Inhibitors in Alzheimer's Treatment

Author(s): F. Ansari, J B. Ghasemi* and A. Niazi
Pages: 1-14 (14)
Novel Coupled Molecules from Active Structural Motifs of Synthetic and Natural Origin as Immunosuppressants

Author(s): Richa Minhas, Gulshan Bansal and Yogita Bansal*
Pages: 1-11 (11)
Design and Biological Evaluation of Novel Imidazolyl Flavonoids as Potent and Selective Protein Tyrosine Phosphatase Inhibitors

Author(s): Rong Ye Han, Yu Ge, Ling Zhang* and Qing Ming Wang
Pages: 1-12 (12)
The use of Sulfonamide Derivatives in the Treatment of Trypanosomatid Parasites including Trypanosoma cruzi, Trypanosoma brucei, and Leishmania ssp

Author(s): Cauê Benito Scarim*, Rafael Consolin Chelucci, Jean Leandro dos Santos and Chung Man Chin
Pages: 1-15 (15)
Synthesis of New Cyclic Imides Derived From Safrole, Structure- and Ligand-based Approaches to Evaluate Potential New Multitarget Agents Against Species of Leishmania

Author(s): José Alixandre de Sousa Luis*, Normando Alexandre da Silva Costa, Cristiane Cosmo Silva Luis, Bruno Freitas Lira, Petrônio Filgueiras Athayde-Filho, Tatjana Keesen de Souza Lima, Juliana da Câmara Rocha, Luciana Scotti and Marcus Tullius Scotti
Pages: 1-12 (12)
Anti-Mycobacterial Peroxides: A New Class of Agents for Development Against Tuberculosis

Author(s): Christiaan W. van der Westhuyzen, Richard K. Haynes, Jenny-Lee Panayides, Ian Wiid and Christopher J. Parkinson*
Pages: 1-11 (11)
First Example of Antiparasitic Activity Influenced by Thermochromism: Leishmanicidal Evaluation of 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine Metal Complexes

Author(s): José M. Méndez-Arriaga*, Itziar Oyarzabal, Álvaro Martín-Montes, Judith García-Rodríguez, Miguel Quirós and Manuel Sánchez-Moreno
Pages: 1-9 (9)
Highly Potent and Selective Ectonucleoside Triphosphate Diphosphohydrolase (ENTPDase1, 2, 3 and 8) Inhibitors Having 2-substituted-7- trifluoromethyl-thiadiazolopyrimidones Scaffold

Author(s): Saira Afzal, Sumera Zaib, Behzad Jafari, Peter Langer, Joanna Lecka, Jean Sévigny and Jamshed Iqbal*
Pages: 1-14 (14)
Hybrids of Coumarin Derivatives as Potent and Multifunctional Bioactive Agents: A Review

Author(s): Ioannis Fotopoulos and Dimitra Hadjipavlou - Litina*
Pages: 1-36 (36)
Design, Synthesis and in vitro Anti-Cancer evaluation of Novel Derivatives of 2-(2-Methyl-1,5-diaryl-1H-pyrrol-3-yl)-2-oxo-N-(pyridin-3-yl)acetamide

Author(s): Ebrahim Saeedian Moghadam, Farhad Saravani, Ernest Hamel, Zahra Shahsavari, Mohsen Alipour, Saman Hosseinkhani, Seyednasser Ostad and Mohsen Amini*
Pages: 1-10 (10)
Inhibitors of Cyclin-Dependent Kinase 1/2 for Anticancer Treatment

Author(s): Jiajia Mou*, Danghui Chen and Yanru Deng
Pages: 1-19 (19)
Synthesis and Biological Evaluation of 5-benzyl-3-pyridyl-1H-1,2,4-triazole Derivatives as Xanthine Oxidase Inhibitors

Author(s): Song-ye Li , Ting-jian Zhang , Qing-xia Wu, O Kamara Mohamed, Yi Zhang and Fan-hao Meng*
Pages: 1-9 (9)
Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives as Potential Anti-Cancer Agents

Author(s): Mona Monir Kamel, Mohamed Kamal Abdel-hameid, Hala Bakr ElNassan* and Eman Adel El-Khouly
Pages: 1-10 (10)
Anti-proliferative Effects of Chromones: Potent Derivatives Affecting Cell Growth and Apoptosis in Breast, Bone-marrow and Cervical Cancer Cells

Author(s): Jamshed Iqbal, Syeda Abida Ejaz, Mariia Miliutina, Peter Langer and Aamer Saeed
Pages: 1-9 (9)
Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors

Author(s): Barbara Cacciari*, Pamela Crepaldi, Chun Yan Cheng, Elena Bossi , Giampiero Spalluto, Stephanie Federico, Kenneth A. Jacobson and Marco Cattaneo
Pages: 1-10 (10)
Recent Advances in Therapeutic Applications of Bisbenzimidazoles

Author(s): Smita Verma , V. Ravichandiran, Nihar Ranjan and S. J.S Flora*
Pages: 1-31 (31)
Antiglycation Activity of Triazole Schiff’s Bases Against Fructosemediated Glycation: In vitro and in silico Study

Author(s): Muniza Shaikh, Salman Siddiqui, Humaira Zafar, Uzma Naqeeb, Fakiha Subzwari, Rehan Imad, Khalid Mohammed Khan and M. Iqbal Choudhary*
Pages: 1-16 (16)
Synthesis, Biological Evaluation and Molecular Dynamics Simulation Studies of Novel Diphenyl Ethers

Author(s): Amol B. Khade, Sidhartha S. Kar, A Cinu Thomas , Ashutosh Tiwari, Mradul Tiwari, K. E. Vandana , Pritesh Bhat, G. Varadaraj Bhat and G. Gautham Shenoy*
Pages: 1-15 (15)
Bicycloheptylamine-Doxorubicin Conjugate: Synthesis and Anticancer Activities in σ2 Receptor-Expressing Cell Lines

Author(s): Mohammed A. Alamri, Zeynep Ates-Alagoz and Adeboye Adejare*
Pages: 1-10 (10)
New Copper Compounds with Antiplatelet Aggregation Activity

Author(s): Mirthala Flores-Garcia, Juan Manuel Fernández-G, Cristina Busqueta-Griera, Elizabeth Gomez, Simon Hernandez-Ortega, Jean Christian Daniel Lamothe-Flores, Virginia Gomez-Vidales, Ana Maria Mejia-Dominguez, Eduardo Angles-Cano and Aurora de la Pena-Diaz*
Pages: 1-13 (13)
Design and Synthesis of New Sulfonamides–Based Flt3 Inhibitors

Author(s): Reem Fawaz Abutayeh, Jehad Almaliti and Mutasem O. Taha*
Pages: 1-10 (10)
Cytotoxicity, Pro-apoptotic Activity and in silico Studies of Dithiocarbamates and their Structure Based Design and SAR Studies

Author(s): Syeda Shamila Hamdani, Bilal Ahmad Khan*, Shahid Hameed, Faisal Rashid, Sumera Zaib, Khalil Ahmed, Ehsan Ullah Mughal and Jamshed Iqbal*
Pages: 1-11 (11)
Synthesis, Anticancer Evaluation and Synergistic Effects with cisplatin of Novel Palladium Complexes: DNA, BSA Interactions and Molecular Docking Study

Author(s): Nenad Joksimović, Nenad Janković, Jelena Petronijević, Dejan Baskić, Suzana Popovic, Danijela Todorović, Milan Zarić, Olivera Klisurić, Milan Vraneš, Aleksandar Tot and Zorica Bugarčić*
Pages: 1-14 (14)
Design and Synthesis of New Substituted Pyrazolopyridines with Potent Antiproliferative Activity

Author(s): Vassiliki Giannouli, Nikolaos Lougiakis, Ioannis K. Kostakis, Nicole Pouli*, Panagiotis Marakos, Alexios-Leandros Skaltsounis, David A. Horne, Sangkil Nam, Katerina Gioti and Roxane Tenta
Pages: 1-16 (16)
Chemistry, Alpha-glucosidase and Radical Scavenging Properties of Uranyl(VI) Hydrazide Complexes

Author(s): Parveen Akhter, Uzma Ashiq*, Rifat Ara Jamal, Zara Shaikh, Mohammad Mahroof-Tahir, Mehreen Lateef and Rooma Badar
Pages: 1-13 (13)
Target Based Virtual Screening of New Leads Inhibitor against Bacterial Cell Division Protein FtsZ for the Discovery of Antibacterial Agents

Author(s): Ratish Chandra Mishra, Rosy Kumari, Shivani Yadav and Jaya Parkash Yadav*
Pages: 1-7 (7)
Structure-activity Relationship Study on Therapeutically Relevant EGFR Double Mutant Inhibitors

Author(s): Shehnaz Fatima and Subhash Mohan Agarwal*
Pages: 1-10 (10)
The Effects of Trifluoromethylated Derivatives on Prostaglandin E2 and Thromboxane A2 Production in Human Leukemic U937 Macrophages

Author(s): Ivana Beara*, Tatjana Majkić, Stefania Fioravanti, Laura Trulli, Neda Mimica-Dukić, Lucio Pellacani and Luciano Saso
Pages: 1-6 (6)
Design, Synthesis, and Anti-bacterial Activity of Novel Deoxycholic Acid- Amino Alcohol Conjugates

Author(s): Satyendra Mishra* and Sejal Patel
Pages: 1-7 (7)
Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents

Author(s): Nikolaos Kollatos, Christos Mitsos, Stella Manta, Niki Tzioumaki, Christos Giannakas, Tania Alexouli, Aggeliki Panagiotopoulou, Dominique Schols, Graciela Andrei and Dimitri Komioti*
Pages: 1-17 (17)
Synthesis of New Hydrazone Derivatives and Evaluation of their Efficacy as Proliferation Inhibitors in Human Cancer Cells

Author(s): Piotr Świątek*, Jolanta Saczko, Nina Rembiałkowska and Julita Kulbacka
Pages: 1-8 (8)
Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus Strains

Author(s): A. Hilgeroth*, K. Yasrebi, S. Suzen, T. Hertlein, K. Ohlsen and M. Lalk
Pages: 1-7 (7)
Benzoylthioureas: Design, Synthesis and Antimycobacterial Evaluation

Author(s): Tiago O. Brito, Lethícia O. Abreu, Karen M. Gomes, Maria C. S. Lourenço, Patricia M. L. Pereira, Sueli F. Yamada-Ogatta, Ângelo de Fàtima, Cesar A. Tisher, Fernando Macedo and Marcelle L. F. Bispo*
Pages: 1-11 (11)
The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents

Author(s): Edward Borowski, Natalia Salewska, Joanna Boros-Majewska, Marcin Serocki, Izabela Chabowska, Maria J. Milewska, Dominik Ziętkowski and Sławomir Milewski*
Pages: 1-12 (12)
Synthesis, Characterization, Antibacterial and Antioxidant Potency of NSubstituted- 2-Sulfanylidene-1,3-Thiazolidin-4-one Derivatives and QSAR Study

Author(s): Harshad Brahmbhatt, Maja Molnar*, Valentina Pavi and Vesna Rastijać
Pages: 1-10 (10)
Evaluation of Cytotoxic Potentials of Some Isoindole-1, 3-Dione Derivatives on HeLa, C6 and A549 Cancer Cell Lines

Author(s): Ayse Tan, Ayse Sahin Yaglioglu, Nurhan Horasan Kishali*, Ertan Sahin and Yunus Kara*
Pages: 1-8 (8)
Design and Synthesis of Novel Sulfonamide-Derived Triazoles and Bioactivity Exploration

Author(s): Shi-Chao He, Hui-Zhen Zhang*, Hai-Juan Zhang, Qing Sun and Cheng-He Zhou
Pages: 1-14 (14)
Pyrrolopyrazoles: Synthesis, Evaluation and Pharmacological Screening as Antidepressant Agents

Author(s): Samar Said Fatahala*, Shahira Nofal, Eman Mahmoud and Rania Helmy Abd El-hameed
Pages: 1-12 (12)

E-Pub Full Text Articles

Novel p-Functionalized Chromen-4-on-3-yl Chalcones Bearing Astonishing Boronic Acid Moiety as MDM2 Inhibitor: Synthesis, Cytotoxic Evaluation and Simulation Studies

Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates

Synthesis, Anticancer Activity on Prostate Cancer Cell Lines and Molecular Modeling Studies of Flurbiprofen-Thioether Derivatives as Potential Target of MetAP (type II)

Cyclic Tripeptide-based Potent and Selective Human SIRT5 Inhibitors

Synthesis and Evaluation of Glycyrrhetic Acid-aromatic Hybrids as Antiinflammatory Agents

Design, Synthesis and Evaluation of 8-Thiosubstituted 1,3,7- Trimethylxanthine Hydrazones with In Vitro Neuroprotective and MAO-B Inhibitory Activities

Design of Inhibitors for Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Enzyme of Leishmania mexicana

Styrylquinoline – A Versatile Scaffold in Medicinal Chemistry

Synthesis of N-Substituted Benzamide Derivatives and their Evaluation as Antitumor Agents

Synthesis, Characterization, Antimicrobial Activity and Anticancer of Some New pyrazolo[1,5-a]pyrimidines and pyrazolo[5,1-c]1,2,4-triazines

Thiazole Compounds as Antiviral Agents: An Update

Molecular Docking and Dynamics Simulation Analysis of Thymoquinone and Thymol Compounds from Nigella Sativa L. that Inhibits P38 Protein: Probable Remedies for Hepatocellular Carcinoma

Synthesis of β-Ketosulfone Derivatives As New Non-Cytotoxic Urease Inhibitors In Vitro

Matrine-Family Alkaloids: Versatile Precursors for Bioactive Modifications

Design, Synthesis and Biological Evaluation of Anti-tuberculosis Agents based on Bedaquiline Structure

Three Dimensional Quantitative Structure Activity Relationship and Pharmacophore Modeling of Tacrine Derivatives as Acetylcholinesterase Inhibitors in Alzheimer's Treatment

Novel Coupled Molecules from Active Structural Motifs of Synthetic and Natural Origin as Immunosuppressants

Design and Biological Evaluation of Novel Imidazolyl Flavonoids as Potent and Selective Protein Tyrosine Phosphatase Inhibitors

The use of Sulfonamide Derivatives in the Treatment of Trypanosomatid Parasites including Trypanosoma cruzi, Trypanosoma brucei, and Leishmania ssp

Synthesis of New Cyclic Imides Derived From Safrole, Structure- and Ligand-based Approaches to Evaluate Potential New Multitarget Agents Against Species of Leishmania

Anti-Mycobacterial Peroxides: A New Class of Agents for Development Against Tuberculosis

First Example of Antiparasitic Activity Influenced by Thermochromism: Leishmanicidal Evaluation of 5,7-dimethyl-1,2,4-triazolo[1,5-a]pyrimidine Metal Complexes

Highly Potent and Selective Ectonucleoside Triphosphate Diphosphohydrolase (ENTPDase1, 2, 3 and 8) Inhibitors Having 2-substituted-7- trifluoromethyl-thiadiazolopyrimidones Scaffold

Hybrids of Coumarin Derivatives as Potent and Multifunctional Bioactive Agents: A Review

Design, Synthesis and in vitro Anti-Cancer evaluation of Novel Derivatives of 2-(2-Methyl-1,5-diaryl-1H-pyrrol-3-yl)-2-oxo-N-(pyridin-3-yl)acetamide

Inhibitors of Cyclin-Dependent Kinase 1/2 for Anticancer Treatment

Synthesis and Biological Evaluation of 5-benzyl-3-pyridyl-1H-1,2,4-triazole Derivatives as Xanthine Oxidase Inhibitors

Synthesis and Cytotoxicity Evaluation of Novel Indole Derivatives as Potential Anti-Cancer Agents

Anti-proliferative Effects of Chromones: Potent Derivatives Affecting Cell Growth and Apoptosis in Breast, Bone-marrow and Cervical Cancer Cells

Structure Activity Relationship of 4-Amino-2-thiopyrimidine Derivatives as Platelet Aggregation Inhibitors

Recent Advances in Therapeutic Applications of Bisbenzimidazoles

Antiglycation Activity of Triazole Schiff’s Bases Against Fructosemediated Glycation: In vitro and in silico Study

Synthesis, Biological Evaluation and Molecular Dynamics Simulation Studies of Novel Diphenyl Ethers

Bicycloheptylamine-Doxorubicin Conjugate: Synthesis and Anticancer Activities in σ2 Receptor-Expressing Cell Lines

New Copper Compounds with Antiplatelet Aggregation Activity

Design and Synthesis of New Sulfonamides–Based Flt3 Inhibitors

Cytotoxicity, Pro-apoptotic Activity and in silico Studies of Dithiocarbamates and their Structure Based Design and SAR Studies

Synthesis, Anticancer Evaluation and Synergistic Effects with cisplatin of Novel Palladium Complexes: DNA, BSA Interactions and Molecular Docking Study

Design and Synthesis of New Substituted Pyrazolopyridines with Potent Antiproliferative Activity

Chemistry, Alpha-glucosidase and Radical Scavenging Properties of Uranyl(VI) Hydrazide Complexes

Target Based Virtual Screening of New Leads Inhibitor against Bacterial Cell Division Protein FtsZ for the Discovery of Antibacterial Agents

Structure-activity Relationship Study on Therapeutically Relevant EGFR Double Mutant Inhibitors

The Effects of Trifluoromethylated Derivatives on Prostaglandin E2 and Thromboxane A2 Production in Human Leukemic U937 Macrophages

Design, Synthesis, and Anti-bacterial Activity of Novel Deoxycholic Acid- Amino Alcohol Conjugates

Design, Synthesis, and Biological Evaluation of Novel C5-Modified Pyrimidine Ribofuranonucleosides as Potential Antitumor or/and Antiviral Agents

Synthesis of New Hydrazone Derivatives and Evaluation of their Efficacy as Proliferation Inhibitors in Human Cancer Cells

Antibacterial Evaluation of Novel Substituted Cycloheptaindoles in Staphylococcus and Enterococcus Strains

Benzoylthioureas: Design, Synthesis and Antimycobacterial Evaluation

The Substantial Improvement of Amphotericin B Selective Toxicity Upon Modification of Mycosamine with Bulky Substituents

Synthesis, Characterization, Antibacterial and Antioxidant Potency of NSubstituted- 2-Sulfanylidene-1,3-Thiazolidin-4-one Derivatives and QSAR Study

Evaluation of Cytotoxic Potentials of Some Isoindole-1, 3-Dione Derivatives on HeLa, C6 and A549 Cancer Cell Lines

Design and Synthesis of Novel Sulfonamide-Derived Triazoles and Bioactivity Exploration

Pyrrolopyrazoles: Synthesis, Evaluation and Pharmacological Screening as Antidepressant Agents