E-Pub Full Text Articles

Discovery of a “Cocktail” of Potential SARS-COV-2 Main Protease Inhibitors through Virtual Screening of Known Chemical Components of Vitex negundo L. (“Lagundi”)

Author(s): Ruel Cayona* and Evelyn Creencia
Pages: 1-18 (18)
Synthesis, Molecular Docking and Mosquitocidal Efficacy of Lawsone and its Derivatives Against the Dengue Vector Aedes aegypti L. (Diptera: Culicidae)

Author(s): Antony Stalin*, Paul Dhivya, Ding Lin, Yue Feng, Antony Cruz Asharaja, Munusamy Rajiv Gandhi, Balakrishnan Senthamarai Kannan, Subramani Kandhasamy, Appadurai Daniel Reegan* and Yuan Chen*
Pages: 1-11 (11)
Synthesis, Molecular Docking and In Vivo Biological Evaluation of Iminostilbene Linked 1,2,3-Triazole Pharmacophores as Promising Anti- Anxiety and Anti-Inflammatory Agents

Author(s): Kariyappa N. Ankali, Javarappa Rangaswamy, Mallappa Shalavadi and Nagaraja Naik*
Pages: 1-13 (13)
Utility of Certain 2-Furanone Derivatives for Synthesis of Different Heterocyclic Compounds and Testing their Anti-cancer Activity

Author(s): Rania Helmy Abd El-Hameed*, Hend Medhat El-Shanbaky and Mosaad Sayed Mohamed
Pages: 1-14 (14)
From Anti-infective Agents to Cancer Therapy: A Drug Repositioning Study Revealed a New Use for Nitrofuran Derivatives

Author(s): Gabriella Ortore*, Giulio Poli, Adriano Martinelli, Tiziano Tuccinardi, Flavio Rizzolio and Isabella Caligiuri
Pages: 1-11 (11)
In vitro Synthesis, Structure Elucidation, and Antioxidant Properties of Platinum(IV)-hydrazide Complexes: Molecular Modeling of Free- Hydrazides Suggested as Potent Lipoxygenase Inhibitor

Author(s): Rooma Badar, Uzma Ashiq *, Rifat Ara Jamal, Parveen Akhter, Mohammad Mahroof-Tahir, Sana Gul and Syed Tahir Ali
Pages: 1-18 (18)
Novel Dipeptides Bearing Sulfonamide as Antimalarial and Antitrypanosomal Agents: Synthesis and Molecular Docking

Author(s): Ogechi Chinelo Ekoh*, Uchechukwu Okoro, David Ugwu, Rafat Ali, Sunday Okafor, Daniel Ugwuja and Solomon Attah
Pages: 1-12 (12)
Multi-target Directed Compounds with Antioxidant and/or Antiinflammatory Properties as Potent Agents for Alzheimer’s Disease

Author(s): Georgios Papagiouvannis*, Panagiotis Theodosis-Nobelos, Panos N. Kourounakis and Eleni A. Rekka
Pages: 1-18 (18)
Synthesis, Antileishmanial Activity and in silico Studies of Aminoguanidine Hydrazones (AGH) and Thiosemicarbazones (TSC) Against Leishmania chagasi Amastigotes

Author(s): Thiago M. de Aquino*, Paulo H. B. França, Érica E. E. S. Rodrigues, Igor J. S. Nascimento, Paulo F. S. Santos-Júnior, Pedro G. V. Aquino, Mariana S. Santos, Aline C. Queiroz, Morgana V. Araújo, Magna S. Alexandre-Moreira, Raiza R. L. Rodrigues, Klinger A. F. Rodrigues, Johnnatan D. Freitas, Jacques Bricard, Mario R. Meneghetti, Jean-Jacques Bourguignon, Martine Schmitt, Edeildo F. da Silva-Júnior* and João X. de Araújo-Júnior
Pages: 1-19 (19)
Design, Synthesis and Evaluation of 2,4,6-substituted Pyrimidine Derivatives as BACE-1 inhibitor: Plausible lead for Alzheimer’s Disease

Author(s): Priti Jain*, Pankaj K Wadhwa and Hemant R Jadhav
Pages: 1-13 (13)
In vitro, in vivo and in silico Antihyperglycemic Activity of Some Semi-synthetic Phytol Derivatives

Author(s): Harish C. Upadhyay, Akansha Mishra, Jyotsana Pandey, Pooja Sharma, Akhilesh K. Tamrakar, Arvind K. Srivastava, Feroz Khan and Santosh K. Srivastava*
Pages: 1-7 (7)
A Combined Approach of Pharmacophore Modeling, QSAR Study, Molecular Docking and In silico ADME/Tox Prediction of 4-Arylthio & 4-Aryloxy-3- Iodopyridine-2(1H)-one Analogs to identify Potential Reverse Transcriptase Inhibitor: Anti-HIV Agents

Author(s): Debadash Panigrahi*, Amiyakanta Mishra, Susanta Kumar Sahu, Mohd. Afzal Azam and C.M. Vyshaag
Pages: 1-37 (37)
Synthesis of Some Novel Benzimidazole Derivatives as Anticancer Agent, and Evaluation for CDK2 Inhibition Activity

Author(s): Rania Helmy Abd El-Hameed, Samar Said Fatahala* and Amira Ibrahim Sayed
Pages: 1-11 (11)
Synthesis, Cytotoxicity, ADMET and Molecular Docking Studies of Some Quinoline-Pyrimidine Hybrid Compounds: 3-(2-Amino-6-arylpyrimidin-4- yl)-4-hydroxy-1-methylquinolin-2(1H)-ones

Author(s): Duong Ngoc Toan*, Nguyen Dinh Thanh*, Mai Xuan Truong and Dinh Thuy Van
Pages: 1-15 (15)
Pyrazoles and Fused Pyrimidines: Synthesis, Structure Elucidation, Antitubercular Activity and Molecular Docking Study

Author(s): Amerah M. Al-Soliemy, Rehab Sabour and Thoraya A. Farghaly*
Pages: 1-18 (18)
Coumarins and Quinolones as Effective Multiple Targeted Agents Versus Covid-19: An In silico Study

Author(s): Mojgan Nejabat, Razieh Ghodsi and Farzin Hadizadeh*
Pages: 1-18 (18)
Piroxicam Analogs: Design, Synthesis, Docking Study and Biological Evaluation as Promising Anti-HIV-1 agents

Author(s): Ali Imani, Sepehr Soleymani, Rouhollah Vahabpour, Zahra Hajimahdi* and Afshin Zarghi*
Pages: 1-11 (11)
Chalcones as Scavengers of HOCl and Inhibitors of Oxidative Burst: Structure-Activity Relationship Studies

Author(s): Thaise Martins, Vera L.M. Silva, Artur M.S. Silva, José L.F.C. Lima, Eduarda Fernandes* and Daniela Ribeiro*
Pages: 1-9 (9)
Synthesis, Cytotoxicity, Anti-migration and Anti-Invasion Activity of Diphyllin Heterocyclic Derivatives

Author(s): Weidong Shen, Haijiao Chen, Miaomiao Wu, Ting Zhang, Li Zhu and Yu Zhao*
Pages: 1-8 (8)
Synthesis, Molecular Docking, BSA, and In-Vitro Reactivation Study of Imidazopyridine Oximes Against Paraoxon Inhibited Acetylcholinesterase

Author(s): Ashima Thakur, Jayant Patwa, Abha Sharma* and Swaran Jeet Singh Flora
Pages: 1-15 (15)
Synthesis and Biological Evaluation of 4-Aminoantipyrine Analogues

Author(s): Houwei Ren, Premnath Dhanaraj, Israel V M V Enoch*, Mosae Selvakumar Paulraj and Indiraleka M
Pages: 1-10 (10)
Synthesis and Clinical Development of Palbociclib: An overview

Author(s): Debabrata Konar, Saurabh Maru, Subhabrata Kar and Kapil Kumar*
Pages: 1-24 (24)
2, 4, 5-Trideoxyhexopyranosides Derivatives of 4’-Demethylepipodophyllotoxin: De novo Synthesis and Anticancer Activity

Author(s): Yapeng Lu, Li Zhu, Rui Cai, Yu Li and Yu Zhao*
Pages: 1-10 (10)
Design, Synthesis, and Pharmacokinetic Evaluation of O-Carbamoyl Tizoxanide Prodrugs

Author(s): Xi He, Wenjun Hu, Fanhua Meng and Xingzhou Li*
Pages: 1-11 (11)
Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and downregulation of c-Myc

Author(s): Raül Agut, Eva Falomir*, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda, J. Fernando Díaz, Fernando Josa-Prado and J. Alberto Marco
Pages: 1-11 (11)
Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

Author(s): Vitor F. Ferreira, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G. S. Lima and Fernando de C. da Silva*
Pages: 1-13 (13)
Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents

Author(s): Haicheng Liu, Yushi Futamura, Honghai Wu, Aki Ishiyama, Taotao Zhang, Tao Shi, Qunxiong Zheng, Masato Iwatsuki, Satoshi Ōmura, Hongbin Zou* and Hiroyuki Osada*
Pages: 1-12 (12)
Computational Study and Synthesis of a New Class of Anticonvulsants with 6 Hz Psychomotor Seizure Test Activity: 2-(1,3-benzodioxol-5-yloxy)- N'-[substituted]-acetohydrazides

Author(s): Praveen Kumar* and Laxmi Tripathi
Pages: 1-18 (18)
Exploring the Selectivity Profile of Sigma Receptor Ligands by Molecular Docking and Pharmacophore Analyses

Author(s): Giada Righetti, Michele Tonelli, Paola Fossa and Elena Cichero*
Pages: 1-15 (15)
Anti-oxidant and Antiproliferative Activities of Mongolian Medicinal Plant Extracts and Structure Isolation of Gnetin - H Compound

Author(s): Altannavch Nyamsambuu, Ashfaque Ahmed, Farjana Yeasmin Khusbu, Sarangerel Oidovsambuu, Md. Asaduzzaman Khan, Xi Zhou, Jun-jiang Fu and Han-Chun Chen*
Pages: 1-11 (11)
Voltage-Dependent Sodium Channel Blocker Anticonvulsants: An Approach to the Structure-Activity Relationship

Author(s): M. del Carmen Salazar-López, J. Alberto Guevara-Salazar*, Mónica G. Arellano-Mendoza, Hugo A. Jiménez-Vázquez, Adriana Benavides and Delia Quintana-Zavala
Pages: 1-23 (23)
Design and Synthesis of Novel Anti-inflammatory/Anti-ulcer Hybrid Molecules with Antioxidant Activity

Author(s): Bhim Bahadur Chaudhari, Alka Bali* and Ajitesh Balaini
Pages: 1-13 (13)
A New Series of Triazolothiadiazines as Potential Anticancer Agents for Targeted Therapy of Non-small Cell Lung and Colorectal Cancers: Design, Synthesis, In silico and In vitro Studies Providing Mechanistic Insight into their Anticancer Potencies

Author(s): Belgin Sever, Mehlika Dilek Altıntop*, Gülşen Akalın Çiftçi and Ahmet Özdemir
Pages: 1-25 (25)
Chemical IN04 Inhibits the Kinase Domain not the ROC Domain of LRRK1: Results from Homology Modeling and Molecular Docking

Author(s): Zhenhang Chen, Weirong Xing and Li Fan*
Pages: 1-11 (11)
Synthesis, Biological Evaluation, and QPLD Studies of Piperazine Derivatives as Potential DPP-IV Inhibitors

Author(s): Reema Abu Khalaf*, Haya Abu Jarad, Tariq Al-Qirim and Dima Sabbah
Pages: 1-8 (8)
Synthesis, Characterization and Biological Studies of Organoselenium trans-Palladium(II) Complexes

Author(s): Ivana Raković, Jovana Bogojeski*, Katarina Mladenović, Angelina Petrović, Vera Divac, Kristina Mihailović, Biljana Popovska Jovicić, Marina Kostić, Predrag Canović, Nevena Milivojević, Marko Zivanović and Ivana Radojević
Pages: 1-16 (16)
Novel 4-Oxo-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylic Acid Derivatives as HIV-1 Integrase Inhibitors: Synthesis, Docking Studies, Molecular Dynamics Simulation and Biological Activities

Author(s): Elnaz Ebrahim Zadeh, Rouhollah Vahabpour, Amirreza Dowlati Beirami, Zahra Hajimahdi and Afshin Zarghi*
Pages: 1-12 (12)
Design, Synthesis, and Anti-Neuroinflammatory Activity of Amide- Containing Dithiolethiones

Author(s): Karrington Craig, Paula Avila and Dennis A. Brown*
Pages: 1-9 (9)
Evaluation of Ligustrazine-Based Synthetic Compounds for their Antiproliferative Effects

Author(s): Syed Nasir Abbas Bukhari*, Nasser Hadal Alotaibi, Waqas Ahmad, Khalid Saad Alharbi, Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Muhammad Masood Ahmad, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja and Muhammad Ajaz Hussain
Pages: 1-7 (7)
Oreganum Vulgare: In-vitro Assessment of Cytotoxicity, Molecular Docking Studies, Antioxidant and Anti-inflammatory Activity in LPS Stimulated RAW 264.7 Cells

Author(s): Reyaz Hassan Mir, Gifty Sawhney, Rohini Verma, Bilal Ahmad, Parveen Kumar, Soni Ranjana, Asha Bhagat, Sreedhar Madishetti, Zabeer Ahmed, Sanjay M Jachak, Sangdun Choi and Mubashir Hussain Masoodi*
Pages: 1-11 (11)
Synthesis and in vitro anti-HCV and Antitumor Evaluation of Schisandronic Acid Derivatives

Author(s): Kai-Xia Zhang, Xi-Jing Qian, Wei-Zheng, Meng-Cheng Cai, Ying Ma, Da-Zhi Zhang, Shi-Chong Yu, Qing-Guo Meng and Yong-Sheng Jin*
Pages: 1-9 (9)
Synthesis and Structure-Activity Relationshπip Studies of N-monosubstituted Aroylthioureas as Urease Inhibitors

Author(s): Wei-Wei Ni, Hai-Lian Fang, Ya-Xi Ye, Wei-Yi Li, Li Liu, Zi-Juan Fu, Dawalamu, Wen-Yan Zhu, Ke Li, Fang Li, Xia Zou, Hui Ouyang, Zhu-Ping Xiao and Hai-Liang Zhu*
Pages: 1-14 (14)
Natural Naphthoquinones Naphthoquinone-based Hydrazone Hybrids: Synthesis and Potent Activity Against Cancer Cell Lines

Author(s): Délis Galvão Guimarães, Arlan de Assis Gonsalves, Larissa Araújo Rolim, Edigênia Cavalcante Araújo, Victória Laysna dos Anjos Santos, Maria Francilene Souza Silva, Fátima de Cássia Evangelista de Oliveira, Marcília Pinheiro da Costa, Claudia Pessoa, Marília Oliveira Fonseca Goulart, Thaissa Lucio Silva, Danyelle Cândido Santos and Cleônia Roberta Melo Araújo*
Pages: 1-11 (11)
Withdrawal Notice: The Design, Synthesis, Pharmacokinetic and Pharmacodynamic Evaluation of Acyloxyalkyl-substituted T705 Prodrugs

Author(s): Xingzhou Li, Tianhong Zhang and Wu Zhong
Pages: 1-1 (1)

E-Pub Full Text Articles

Discovery of a “Cocktail” of Potential SARS-COV-2 Main Protease Inhibitors through Virtual Screening of Known Chemical Components of Vitex negundo L. (“Lagundi”)

Synthesis, Molecular Docking and Mosquitocidal Efficacy of Lawsone and its Derivatives Against the Dengue Vector Aedes aegypti L. (Diptera: Culicidae)

Synthesis, Molecular Docking and In Vivo Biological Evaluation of Iminostilbene Linked 1,2,3-Triazole Pharmacophores as Promising Anti- Anxiety and Anti-Inflammatory Agents

Utility of Certain 2-Furanone Derivatives for Synthesis of Different Heterocyclic Compounds and Testing their Anti-cancer Activity

From Anti-infective Agents to Cancer Therapy: A Drug Repositioning Study Revealed a New Use for Nitrofuran Derivatives

In vitro Synthesis, Structure Elucidation, and Antioxidant Properties of Platinum(IV)-hydrazide Complexes: Molecular Modeling of Free- Hydrazides Suggested as Potent Lipoxygenase Inhibitor

Novel Dipeptides Bearing Sulfonamide as Antimalarial and Antitrypanosomal Agents: Synthesis and Molecular Docking

Multi-target Directed Compounds with Antioxidant and/or Antiinflammatory Properties as Potent Agents for Alzheimer’s Disease

Synthesis, Antileishmanial Activity and in silico Studies of Aminoguanidine Hydrazones (AGH) and Thiosemicarbazones (TSC) Against Leishmania chagasi Amastigotes

Design, Synthesis and Evaluation of 2,4,6-substituted Pyrimidine Derivatives as BACE-1 inhibitor: Plausible lead for Alzheimer’s Disease

In vitro, in vivo and in silico Antihyperglycemic Activity of Some Semi-synthetic Phytol Derivatives

A Combined Approach of Pharmacophore Modeling, QSAR Study, Molecular Docking and In silico ADME/Tox Prediction of 4-Arylthio & 4-Aryloxy-3- Iodopyridine-2(1H)-one Analogs to identify Potential Reverse Transcriptase Inhibitor: Anti-HIV Agents

Synthesis of Some Novel Benzimidazole Derivatives as Anticancer Agent, and Evaluation for CDK2 Inhibition Activity

Synthesis, Cytotoxicity, ADMET and Molecular Docking Studies of Some Quinoline-Pyrimidine Hybrid Compounds: 3-(2-Amino-6-arylpyrimidin-4- yl)-4-hydroxy-1-methylquinolin-2(1H)-ones

Pyrazoles and Fused Pyrimidines: Synthesis, Structure Elucidation, Antitubercular Activity and Molecular Docking Study

Coumarins and Quinolones as Effective Multiple Targeted Agents Versus Covid-19: An In silico Study

Piroxicam Analogs: Design, Synthesis, Docking Study and Biological Evaluation as Promising Anti-HIV-1 agents

Chalcones as Scavengers of HOCl and Inhibitors of Oxidative Burst: Structure-Activity Relationship Studies

Synthesis, Cytotoxicity, Anti-migration and Anti-Invasion Activity of Diphyllin Heterocyclic Derivatives

Synthesis, Molecular Docking, BSA, and In-Vitro Reactivation Study of Imidazopyridine Oximes Against Paraoxon Inhibited Acetylcholinesterase

Synthesis and Biological Evaluation of 4-Aminoantipyrine Analogues

Synthesis and Clinical Development of Palbociclib: An overview

2, 4, 5-Trideoxyhexopyranosides Derivatives of 4’-Demethylepipodophyllotoxin: De novo Synthesis and Anticancer Activity

Design, Synthesis, and Pharmacokinetic Evaluation of O-Carbamoyl Tizoxanide Prodrugs

Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and downregulation of c-Myc

Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents

Computational Study and Synthesis of a New Class of Anticonvulsants with 6 Hz Psychomotor Seizure Test Activity: 2-(1,3-benzodioxol-5-yloxy)- N'-[substituted]-acetohydrazides

Exploring the Selectivity Profile of Sigma Receptor Ligands by Molecular Docking and Pharmacophore Analyses

Anti-oxidant and Antiproliferative Activities of Mongolian Medicinal Plant Extracts and Structure Isolation of Gnetin - H Compound

Voltage-Dependent Sodium Channel Blocker Anticonvulsants: An Approach to the Structure-Activity Relationship

Design and Synthesis of Novel Anti-inflammatory/Anti-ulcer Hybrid Molecules with Antioxidant Activity

A New Series of Triazolothiadiazines as Potential Anticancer Agents for Targeted Therapy of Non-small Cell Lung and Colorectal Cancers: Design, Synthesis, In silico and In vitro Studies Providing Mechanistic Insight into their Anticancer Potencies

Chemical IN04 Inhibits the Kinase Domain not the ROC Domain of LRRK1: Results from Homology Modeling and Molecular Docking

Synthesis, Biological Evaluation, and QPLD Studies of Piperazine Derivatives as Potential DPP-IV Inhibitors

Synthesis, Characterization and Biological Studies of Organoselenium trans-Palladium(II) Complexes

Novel 4-Oxo-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylic Acid Derivatives as HIV-1 Integrase Inhibitors: Synthesis, Docking Studies, Molecular Dynamics Simulation and Biological Activities

Design, Synthesis, and Anti-Neuroinflammatory Activity of Amide- Containing Dithiolethiones

Evaluation of Ligustrazine-Based Synthetic Compounds for their Antiproliferative Effects

Oreganum Vulgare: In-vitro Assessment of Cytotoxicity, Molecular Docking Studies, Antioxidant and Anti-inflammatory Activity in LPS Stimulated RAW 264.7 Cells

Synthesis and in vitro anti-HCV and Antitumor Evaluation of Schisandronic Acid Derivatives

Synthesis and Structure-Activity Relationshπip Studies of N-monosubstituted Aroylthioureas as Urease Inhibitors

Natural Naphthoquinones Naphthoquinone-based Hydrazone Hybrids: Synthesis and Potent Activity Against Cancer Cell Lines

Withdrawal Notice: The Design, Synthesis, Pharmacokinetic and Pharmacodynamic Evaluation of Acyloxyalkyl-substituted T705 Prodrugs