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Neuropharmacological Screening of Chiral and Non-chiral Phthalimide- Containing Compounds in Mice: in vivo and in silico Experiments

Author(s): Carolina Campos-Rodriguez, Jose G. Trujillo-Ferrara*, Ameyali Alvarez-Guerra, Iran M. Cumbres Vargas, Roberto I. Cuevas-Hernandez, Erik Andrade-Jorge, Sergio Zamudio and Eduardo Ramirez-San Juan*
Pages: 1-17 (17)
Synthesis and Biological Evaluation of Novel 2,3-disubstituted Benzofuran Analogues of GABA as Neurotropic Agents

Author(s): Arturo Coaviche-Yoval, Hector Luna, Ricardo Tovar-Miranda, Marvin Antonio Soriano-Ursua and Jose G. Trujillo-Ferrara*
Pages: 1-10 (10)
Novel Hydroxamic Acids Incorporating 1-((1H-1,2,3-Triazol-4-yl)methyl)- 3-substituted-2-oxoindolines: Synthesis, Biological Evaluation and SAR Analysis

Author(s): Do Thi Mai Dung, Nguyen Van Huan, Do Manh Cam, Dao Cam Hieu, Pham-The Hai, Le-Thi-Thu Huong, Jisung Kim, Jeong Eun Choi, Jong Soon Kang, Sang-Bae Han* and Nguyen-Hai Nam*
Pages: 1-20 (20)
The Evaluation of Metal Co-ordinating Bis-Thiosemicarbazones as Potential Anti-malarial Agents

Author(s): Fady N. Akladios, Scott D. Andrew, Samantha J. Boog, Carmen de Kock, Richard K. Haynes and Christopher J. Parkinson*
Pages: 1-8 (8)
2-Oxo-1,2,3,4-tetrahydropyrimidines as Potent β-Glucuronidase Inhibitors: One-pot Synthesis, In vitro and In silico Studies

Author(s): Sarosh Iqbal*, Nimra Naveed Shaikh, Khalid Mohammed Khan*, Sehrish Naz, Zaheer Ul-Haq Qasmi, Shahnaz Perveen and M. Iqbal Choudhary*
Pages: 1-12 (12)
Pyrano[3,2-c]quinoline Derivatives as New Class of α-glucosidase Inhibitors to Treat Type 2 Diabetes: Synthesis, in vitro Biological Evaluation and Kinetic Study

Author(s): Zahra Heydari, Maryam Mohammadi-Khanaposhtani, Somaye Imanparast, Mohammad Ali Faramarzi, Mohammad Mahdavi *, Parviz Rashidi Ranjbar* and Bagher Larijani
Pages: 1-9 (9)
4-Hydroxy-2-pyridone Derivatives and the δ-pyrone Isostere as Novel Agents Against Mycobacterium smegmatis Biofilm Inhibitors

Author(s): Maheshkumar R. Borkar, Santosh Nandan*, M N Harish Kumar , Jayashree Puttur, M Jisha , Dipankar Chatterji and Evans C. Coutinho *
Pages: 1-10 (10)
Homopiperazine Derived Female Controlled Vaginal Trichomonacidal Contraceptive: An Addition to Structure-Activity Relationship

Author(s): B. S. Rahul , Bindu Saraswati, C. Shiju, Gopal Gupta and Nand Lal*
Pages: 1-11 (11)
Design, Synthesis and Biological Evaluation of New 1,3-diphenyl-3- (phenylamino)propan-1-ones as Selective Cyclooxygenase (COX-2) Inhibitors

Author(s): Shabnam Farzaneh, Soraya Shahhosseini, Hadi Arefi, Bahram Daraei, Marjan Esfahanizadeh and Afshin Zarghi*
Pages: 1-8 (8)
Design, Synthesis and Biological Evaluation of 1H-1,2,3-Triazole-Linked- 1H

Author(s): Carolina S. Bortolot, Luana da S. M. Forezi, Roberta K. F. Marra, Marcelo I. P. Reis, Barbara V. F. e Sa, Ricardo Imbroisi Filho, Zeinab Ghasemishahrestani, Mauro Sola-Penna, Patricia Zancan, Vitor F. Ferreira* and Fernando de C. da Silva*
Pages: 1-11 (11)
Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and Aβ-Aggregation Inhibitors

Author(s): Burcu Kilic, Merve Erdogan, Hayrettin O. Gulcan, Fatma Aksakal, Nihan Oruklu, E. Umit Bagriacik and Deniz S. Dogruer*
Pages: 1-18 (18)
Exploration of (hetero)aryl Derived Thienylchalcones for Antiviral and Anticancer Activities

Author(s): Vikrant Patil, Siddappa A. Patil*, Renukadevi Patil, Alejandro Bugarin, Kenneth Beaman and Shivaputra A. Patil*
Pages: 1-12 (12)
Antimicrobial Evaluation of Erythrinan Alkaloids from Erythrina cristagalli L.

Author(s): Janaina M. de Avila, Ionara I. Dalcol*, Alessandra O. Pereira, Eveline W. Santos, Adriano Ferraz, Maura Z. Santos, Marco Aurelio Mostardeiro and Ademir F. Morel
Pages: 1-7 (7)
Sorbinil, an Aldolase Reductase Inhibitor, in Fighting Against Diabetic Complications

Author(s): Qi Huang, Qiong Liu and Dongsheng Ouyang*
Pages: 1-5 (5)
Synthesis of Nucleosides and Non-nucleosides Based 4,6-disubstituted-2- oxo-dihydropyridine-3-carbonitriles as Antiviral Agents

Author(s): Tarek S. Ibrahim, Hassan A. El-Sayed, Maan T. Khayat, Amany M.M. AL-Mahmoudy, Ahmed H. Moustafa, Ayat K. Saad El-Deen, Sherif A.F. Rostom and Siva S. Panda*
Pages: 1-18 (18)
QSAR and Pharmacophore Mapping Studies on Benzothiazinimines to Relate their Structural Features with anti-HIV Activity

Author(s): Gopiraja Geethaavacini, Go Poh Poh, Lim Yi Yan, Rajindran Deepashini , Sivadasan Shalini, Rajak Harish, Krishnan Sureshkumar and Veerasamy Ravichandran*
Pages: 1-8 (8)
Crystal Structure of Mistletoe Lectin I (ML-I) from Viscum album in Complex with 4-N-Furfurylcytosine at 2.85 Å Resolution

Author(s): Malik Shoaib Ahmad*, Saima Rasheed, Sven Falke, Binish Khaliq, Markus Perbandt, M. Iqbal Choudhary, Wojciech T. Markiewicz, Jan Barciszewski and Christian Betzel*
Pages: 1-10 (10)
Inhibition of Mutated Isocitrate Dehydrogenase 1 in Cancer

Author(s): Fangrui Wu, Gang Cheng, Yuan Yao, Mari Kogiso, Hong Jiang, Xiao-Nan Li and Yongcheng Song*
Pages: 1-10 (10)
Pyrazole and imidazo[1,2-b]pyrazole Derivatives as New Potential Antituberculosis Agents

Author(s): Elda Meta, Chiara Brullo*, Michele Tonelli, Scott G. Franzblau, Yuehong Wang, Rui Ma, Wan Baojie , Beatrice Silvia Orena, Maria Rosalia Pasca and Olga Bruno
Pages: 1-11 (11)
Design of Bactericidal Peptides Against Escherichia coli O157:H7, Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus

Author(s): Jenniffer Cruz, Paola Rondon , Rodrigo Torres, Mauricio Urquiza, Fanny Guzman, Claudio Alvarez, Maria Angeles Abengozar, Daniel A. Sierra, Luis Rivas, Roberto Fernandez-Lafuente and Claudia Ortiz*
Pages: 1-12 (12)
Synthetic Diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates Induce Apoptosis

Author(s): Seunghyun Ahn, Youngshim Lee, Jihyun Park, Junho Lee, Soon Young-Shin, Young Han Lee, Dongsoo Koh* and Yoongho Lim*
Pages: 1-12 (12)
Diclofenac 1,3,4-Oxadiazole Derivatives; Biology-Oriented Drug Synthesis (BIODS) in Search of Better Non-Steroidal, Non-Acid Antiinflammatory Agents

Author(s): Shazia Shah, Arshia, Nida Siraj Kazmi, Almas Jabeen, Aisha Faheem, Nida Dastagir, Tariq Ahmed, Khalid Mohammed Khan*, Shakil Ahmed, Abeer Raza and Shahnaz Perveen
Pages: 1-14 (14)
Benzoin Schiff Bases: Design, Synthesis, and Biological Evaluation as Potential Antitumor Agents

Author(s): Dima A. Sabbah*, Fatima Al-Tarawneh, Wamidh H. Talib, Kamal Sweidan, Sanaa K. Bardaweel, Eveen Al-Shalabi, Haizhen A. Zhong, Ghassan Abu Sheikha, Reema Abu Khalaf and Mohammad S. Mubarak
Pages: 1-14 (14)
An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist

Author(s): Lena Trifonov, Michal Afri, Krzysztof Palczewski, Edward E. Korshin* and Arie Gruzman*
Pages: 1-7 (7)
Synthesis, cyclooxygenase-2 Inhibition, anti-inflammatory Evaluation and Docking Study of Substituted-N-(3,4,5-trimethoxyphenyl)-benzo[d]oxazole Derivatives

Author(s): Avneet Kaur*, Sharad Wakode , Dharam Pal Pathak, Vidushi Sharma and Ashok K Shakya
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Synthesis of a Tyr-Tyr Dipeptide Library and Evaluation Against Tumor Cells

Author(s): Stanley NS Vasconcelos, Juliana M. Sciani, Nicole Mambeli Lisboa and Helio A Stefani*
Pages: 1-6 (6)
Synthesis and Biological Evaluation of 12N-substituted Tricyclic Matrinic Derivatives as a Novel Family of Anti-Influenza Agents

Author(s): Sheng Tang, Yu-Huan Li , Xin–Yue Cheng, Jin–Qiu Yin , Ying–Hong Li , Dan–Qing Song , Yan–Xiang Wang * and Zhan–Dong Liu
Pages: 1-9 (9)
Identification of New Chromenone Derivatives as Cholinesterase Inhibitors and Molecular Docking Studies

Author(s): Jamshed Iqbal *, Muhammad Shakeel Ahmad Abbasi, Sumera Zaib , Saifullah Afridi, Norbert Furtmann, Jurgen Bajorath and Peter Langer
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Synthesis and Characterization of Thiocarbohydrazones and their Inhibitory Potential Against Ignored Disease Leishmaniasis

Author(s): Nida Ghouri*, Khalid Mohammed Khan, Arshia, M Iqbal Choudhary and Shahnaz Perveen
Pages: 1-8 (8)

E-Pub Full Text Articles

Neuropharmacological Screening of Chiral and Non-chiral Phthalimide- Containing Compounds in Mice: in vivo and in silico Experiments

Synthesis and Biological Evaluation of Novel 2,3-disubstituted Benzofuran Analogues of GABA as Neurotropic Agents

Novel Hydroxamic Acids Incorporating 1-((1H-1,2,3-Triazol-4-yl)methyl)- 3-substituted-2-oxoindolines: Synthesis, Biological Evaluation and SAR Analysis

The Evaluation of Metal Co-ordinating Bis-Thiosemicarbazones as Potential Anti-malarial Agents

2-Oxo-1,2,3,4-tetrahydropyrimidines as Potent β-Glucuronidase Inhibitors: One-pot Synthesis, In vitro and In silico Studies

Pyrano[3,2-c]quinoline Derivatives as New Class of α-glucosidase Inhibitors to Treat Type 2 Diabetes: Synthesis, in vitro Biological Evaluation and Kinetic Study

4-Hydroxy-2-pyridone Derivatives and the δ-pyrone Isostere as Novel Agents Against Mycobacterium smegmatis Biofilm Inhibitors

Homopiperazine Derived Female Controlled Vaginal Trichomonacidal Contraceptive: An Addition to Structure-Activity Relationship

Design, Synthesis and Biological Evaluation of New 1,3-diphenyl-3- (phenylamino)propan-1-ones as Selective Cyclooxygenase (COX-2) Inhibitors

Design, Synthesis and Biological Evaluation of 1H-1,2,3-Triazole-Linked- 1H

Design, Synthesis and Investigation of New Diphenyl Substituted Pyridazinone Derivatives as Both Cholinesterase and Aβ-Aggregation Inhibitors

Exploration of (hetero)aryl Derived Thienylchalcones for Antiviral and Anticancer Activities

Antimicrobial Evaluation of Erythrinan Alkaloids from Erythrina cristagalli L.

Sorbinil, an Aldolase Reductase Inhibitor, in Fighting Against Diabetic Complications

Synthesis of Nucleosides and Non-nucleosides Based 4,6-disubstituted-2- oxo-dihydropyridine-3-carbonitriles as Antiviral Agents

QSAR and Pharmacophore Mapping Studies on Benzothiazinimines to Relate their Structural Features with anti-HIV Activity

Crystal Structure of Mistletoe Lectin I (ML-I) from Viscum album in Complex with 4-N-Furfurylcytosine at 2.85 Å Resolution

Inhibition of Mutated Isocitrate Dehydrogenase 1 in Cancer

Pyrazole and imidazo[1,2-b]pyrazole Derivatives as New Potential Antituberculosis Agents

Design of Bactericidal Peptides Against Escherichia coli O157:H7, Pseudomonas aeruginosa and methicillin-resistant Staphylococcus aureus

Synthetic Diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates Induce Apoptosis

Diclofenac 1,3,4-Oxadiazole Derivatives; Biology-Oriented Drug Synthesis (BIODS) in Search of Better Non-Steroidal, Non-Acid Antiinflammatory Agents

Benzoin Schiff Bases: Design, Synthesis, and Biological Evaluation as Potential Antitumor Agents

An Expedient Synthesis of CMF-019: (S)-5-Methyl-3-{1-(pentan-3-yl)-2- (thiophen-2-ylmethyl)-1H-benzo[d]imidazole-5-carboxamido}hexanoic Acid, a Potent Apelin Receptor (APJ) Agonist

Synthesis, cyclooxygenase-2 Inhibition, anti-inflammatory Evaluation and Docking Study of Substituted-N-(3,4,5-trimethoxyphenyl)-benzo[d]oxazole Derivatives

Synthesis of a Tyr-Tyr Dipeptide Library and Evaluation Against Tumor Cells

Synthesis and Biological Evaluation of 12N-substituted Tricyclic Matrinic Derivatives as a Novel Family of Anti-Influenza Agents

Identification of New Chromenone Derivatives as Cholinesterase Inhibitors and Molecular Docking Studies

Synthesis and Characterization of Thiocarbohydrazones and their Inhibitory Potential Against Ignored Disease Leishmaniasis