E-Pub Full Text Articles

2, 4, 5-Trideoxyhexopyranosides Derivatives of 4’-Demethylepipodophyllotoxin: De novo Synthesis and Anticancer Activity

Author(s): Yapeng Lu, Li Zhu, Rui Cai, Yu Li and Yu Zhao*
Pages: 1-10 (10)
Design, Synthesis, and Pharmacokinetic Evaluation of O-Carbamoyl Tizoxanide Prodrugs

Author(s): Xi He, Wenjun Hu, Fanhua Meng and Xingzhou Li*
Pages: 1-11 (11)
Synthesis, Cytotoxicity, Anti-migration and Anti-invasion Activity of Diphyllin Heterocyclic Derivatives

Author(s): Weidong Shen, Haijiao Chen, Miaomiao Wu, Ting Zhang, Li Zhu and Yu Zhao*
Pages: 1-9 (9)
Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and downregulation of c-Myc

Author(s): Raül Agut, Eva Falomir*, Juan Murga, Celia Martín-Beltrán, Raquel Gil-Edo, Alberto Pla, Miguel Carda, J. Fernando Díaz, Fernando Josa-Prado and J. Alberto Marco
Pages: 1-11 (11)
Site-directed Fragnomics and MD Simulations Approaches to Identify Interleukin-2 Inhibitors

Author(s): Ruqaiya Khalil, Saman Usmani, Mohammad Nur-e-Alam, Sarfaraz Ahmed and Zaheer Ul-Haq*
Pages: 1-11 (11)
Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

Author(s): Vitor F. Ferreira, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G. S. Lima and Fernando de C. da Silva*
Pages: 1-13 (13)
Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents

Author(s): Haicheng Liu, Yushi Futamura, Honghai Wu, Aki Ishiyama, Taotao Zhang, Tao Shi, Qunxiong Zheng, Masato Iwatsuki, Satoshi Ōmura, Hongbin Zou* and Hiroyuki Osada*
Pages: 1-12 (12)
Computational Study and Synthesis of a New Class of Anticonvulsants with 6 Hz Psychomotor Seizure Test Activity: 2-(1,3-benzodioxol-5-yloxy)- N'-[substituted]-acetohydrazides

Author(s): Praveen Kumar* and Laxmi Tripathi
Pages: 1-18 (18)
Exploring the Selectivity Profile of Sigma Receptor Ligands by Molecular Docking and Pharmacophore Analyses

Author(s): Giada Righetti, Michele Tonelli, Paola Fossa and Elena Cichero*
Pages: 1-15 (15)
Anti-oxidant and Antiproliferative Activities of Mongolian Medicinal Plant Extracts and Structure Isolation of Gnetin - H Compound

Author(s): Altannavch Nyamsambuu, Ashfaque Ahmed, Farjana Yeasmin Khusbu, Sarangerel Oidovsambuu, Md. Asaduzzaman Khan, Xi Zhou, Jun-jiang Fu and Han-Chun Chen*
Pages: 1-11 (11)
Synthesis and Clinical Development of Palbociclib: An overview

Author(s): Debabrata Konar, Saurabh Maru, Subhabrata Kar and Kapil Kumar*
Pages: 1-27 (27)
Multi-target Directed Compounds with Antioxidant and/or Antiinflammatory Properties as Potent Agents for Alzheimer’s Disease

Author(s): Papagiouvannis Georgios*, Theodosis-Nobelos Panagiotis, Kourounakis N. Panos and Rekka A. Eleni
Pages: 1-18 (18)
Antidiabetic and Antioxidative Properties of Novel Zn(II)-cinnamic Acid Complex

Author(s): Chika I. Chukwuma*, Samson S. Mashele and Shasank S. Swain
Pages: 1-13 (13)
Exploring the Molecular Mechanisms of 17β-HSD5-induced Carcinogenicity of Catha edulis via Molecular Modeling Approach

Author(s): Maria Saeed, Sajda Ashraf, Rashad Alsanosi, Hassan A. Alhazmi, Mohammed AlBratty, Asim Najmi, Asaad Khalid and Zaheer ul Haq*
Pages: 1-11 (11)
Voltage-Dependent Sodium Channel Blocker Anticonvulsants: An Approach to the Structure-Activity Relationship

Author(s): M. del Carmen Salazar-López, J. Alberto Guevara-Salazar*, Mónica G. Arellano-Mendoza, Hugo A. Jiménez-Vázquez, Adriana Benavides and Delia Quintana-Zavala
Pages: 1-23 (23)
Design and Synthesis of Novel Anti-inflammatory/Anti-ulcer Hybrid Molecules with Antioxidant Activity

Author(s): Bhim Bahadur Chaudhari, Alka Bali* and Ajitesh Balaini
Pages: 1-13 (13)
Synthesis and biological evaluation of 4-aminoantipyrine analogues

Author(s): Houwei Ren, Premnath Dhanaraj, Israel V M V Enoch*, Mosae Selvakumar Paulraj and Indiraleka M
Pages: 1-13 (13)
A New Series of Triazolothiadiazines as Potential Anticancer Agents for Targeted Therapy of Non-small Cell Lung and Colorectal Cancers: Design, Synthesis, In silico and In vitro Studies Providing Mechanistic Insight into their Anticancer Potencies

Author(s): Belgin Sever, Mehlika Dilek Altıntop*, Gülşen Akalın Çiftçi and Ahmet Özdemir
Pages: 1-25 (25)
Chemical IN04 Inhibits the Kinase Domain not the ROC Domain of LRRK1: Results from Homology Modeling and Molecular Docking

Author(s): Zhenhang Chen, Weirong Xing and Li Fan*
Pages: 1-11 (11)
Synthesis, Biological Evaluation, and QPLD Studies of Piperazine Derivatives as Potential DPP-IV Inhibitors

Author(s): Reema Abu Khalaf*, Haya Abu Jarad, Tariq Al-Qirim and Dima Sabbah
Pages: 1-8 (8)
Synthesis, Characterization and Biological Studies of Organoselenium trans-Palladium(II) Complexes

Author(s): Ivana Raković, Jovana Bogojeski*, Katarina Mladenović, Angelina Petrović, Vera Divac, Kristina Mihailović, Biljana Popovska Jovicić, Marina Kostić, Predrag Canović, Nevena Milivojević, Marko Zivanović and Ivana Radojević
Pages: 1-16 (16)
Novel 4-Oxo-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylic Acid Derivatives as HIV-1 Integrase Inhibitors: Synthesis, Docking Studies, Molecular Dynamics Simulation and Biological Activities

Author(s): Elnaz Ebrahim Zadeh, Rouhollah Vahabpour, Amirreza Dowlati Beirami, Zahra Hajimahdi and Afshin Zarghi*
Pages: 1-12 (12)
Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer

Author(s): Jamshed Iqbal*, Ayesha Basharat, Sehrish Bano, Syed Mobasher Ali Abid, Julie Pelletier and Jean Sévigny
Pages: 1-9 (9)
Design, Synthesis, and Anti-Neuroinflammatory Activity of Amide- Containing Dithiolethiones

Author(s): Karrington Craig, Paula Avila and Dennis A. Brown*
Pages: 1-9 (9)
Evaluation of Ligustrazine-Based Synthetic Compounds for their Antiproliferative Effects

Author(s): Syed Nasir Abbas Bukhari*, Nasser Hadal Alotaibi, Waqas Ahmad, Khalid Saad Alharbi, Mohamed A. Abdelgawad, Mohammad M. Al-Sanea, Muhammad Masood Ahmad, Muhammad Wahab Amjad, Maria Abdul Ghafoor Raja and Muhammad Ajaz Hussain
Pages: 1-7 (7)
Oreganum Vulgare: In-vitro Assessment of Cytotoxicity, Molecular Docking Studies, Antioxidant and Anti-inflammatory Activity in LPS Stimulated RAW 264.7 Cells

Author(s): Reyaz Hassan Mir, Gifty Sawhney, Rohini Verma, Bilal Ahmad, Parveen Kumar, Soni Ranjana, Asha Bhagat, Sreedhar Madishetti, Zabeer Ahmed, Sanjay M Jachak, Sangdun Choi and Mubashir Hussain Masoodi*
Pages: 1-11 (11)
Synthesis and Evaluation of Cytotoxicity of Novel Coumarin Peptide Alcohol Derivatives

Author(s): Digamber S. Pawar, Vasant V. Chabukswar*, Savita R. Tapase, Kisan M. Kodam, Anurudhha Chabukswar, Pravin B. Adhav, Balasaheb B. Diwate, Sunita Salunke Gawali, Sabrina Dallavalle and Swati C. Jagdale
Pages: 1-11 (11)
Synthesis and in vitro anti-HCV and Antitumor Evaluation of Schisandronic Acid Derivatives

Author(s): Kai-Xia Zhang, Xi-Jing Qian, Wei-Zheng, Meng-Cheng Cai, Ying Ma, Da-Zhi Zhang, Shi-Chong Yu, Qing-Guo Meng and Yong-Sheng Jin*
Pages: 1-9 (9)
Indane-1,3-diones: As Potential and Selective α-glucosidase Inhibitors, their Synthesis, in vitro and in silico Studies

Author(s): Asma Mukhtar, Shazia Shah, Kanwal, Shehryar Hameed, Khalid Mohammed Khan*, Shahid Ullah Khan, Sumera Zaib, Jamshed Iqbal and Shahnaz Parveen
Pages: 1-16 (16)
Design, Synthesis, Pharmacological evaluation, in silico modeling, prediction of toxicity and metabolism studies of novel 1-(substituted)-2-methyl-3-(4-oxo-2-phenyl quinazolin-3(4H)-yl)isothioureas

Author(s): M. T. Sulthana, V. Alagarsamy* and K. Chitra
Pages: 1-17 (17)
Synthesis and Structure-Activity Relationshπip Studies of N-monosubstituted Aroylthioureas as Urease Inhibitors

Author(s): Wei-Wei Ni, Hai-Lian Fang, Ya-Xi Ye, Wei-Yi Li, Li Liu, Zi-Juan Fu, Dawalamu, Wen-Yan Zhu, Ke Li, Fang Li, Xia Zou, Hui Ouyang, Zhu-Ping Xiao and Hai-Liang Zhu*
Pages: 1-14 (14)
Natural Naphthoquinones Naphthoquinone-based Hydrazone Hybrids: Synthesis and Potent Activity Against Cancer Cell Lines

Author(s): Délis Galvão Guimarães, Arlan de Assis Gonsalves, Larissa Araújo Rolim, Edigênia Cavalcante Araújo, Victória Laysna dos Anjos Santos, Maria Francilene Souza Silva, Fátima de Cássia Evangelista de Oliveira, Marcília Pinheiro da Costa, Claudia Pessoa, Marília Oliveira Fonseca Goulart, Thaissa Lucio Silva, Danyelle Cândido Santos and Cleônia Roberta Melo Araújo*
Pages: 1-11 (11)
In silico Study to Evaluate the Antiviral Activity of Novel Structures against 3C-like Protease of Novel Coronavirus (COVID-19) and SARSCoV

Author(s): Kiran Chunduru*, Runali Sankhe*, Farmiza Begum, Nalini Sodum, Nitesh Kumar, Anoop Kishore, Rekha R. Shenoy, C. Mallikarjuna Rao and Kavitha Saravu
Pages: 1-16 (16)
Xanthone: A Promising Antimycobacterial Scaffold

Author(s): Tilal Elsaman, Malik Suliman Mohamed, Eyman Mohamed Eltayib, Abualgasim Elgaili Abdalla and Magdi Awadalla Mohamed*
Pages: 1-22 (22)
Chalcones: As Potent α-amylase Enzyme Inhibitors; Synthesis, In Vitro, and In Silico Studies

Author(s): Mahboob Ali, Momin Khan, Khair Zaman, Abdul Wadood, Maryam Iqbal, Aftab Alam, Sana Shah, Ashfaq Ur Rehman, Muhammad Yousaf, Rafaila Rafique and Khalid Mohammed Khan*
Pages: 1-10 (10)
Design and Synthesis of Arylnaphthalene Lignan Lactone Derivatives as Potent Topoisomerase Inhibitors

Author(s): Wang Chen, Zili Feng*, Daihua Hu and Jin Meng
Pages: 1-10 (10)
Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies

Author(s): Taibi Ben Hadda, Fatma Sezer Senol Deniz, Ilkay Erdogan Orhan, Hsaine Zgou, Abdur Rauf, Yahia Nasser Mabkhot, Brahim Bennani, Dalia R. Emam, Nabila Abdelshafy Kheder, Abdulrhman Asayari, Abdullatif Bin Muhsinah and Aneela Maalik*
Pages: 1-10 (10)
Synthesis of Novel 1,2,3-Triazole Derivatives of Isocoumarins and 3,4- Dihydroisocoumarin with Potential Antiplasmodial Activity In Vitro

Author(s): Lucas da Silva Santos, Matheus Fillipe Langanke de Carvalho, Ana Claudia de Souza Pinto, Amanda Luisa da Fonseca, Julio César Dias Lopes, Fernando de Pilla Varotti, Rossimiriam Pereira de Freitas and Rosemeire Brondi Alves*
Pages: 1-14 (14)
Pyrazole Derivatives of Medically Relevant Phenolic Acids: Insight into Antioxidative and Anti-LOX Activity

Author(s): Vesna Milovanović, Zorica D. Petrović*, Slađana Novaković, Goran A. Bogdanović, Dušica Simijonović, Milan Mladenović, Jovica Branković and Vladimir P. Petrović
Pages: 1-13 (13)
Synthesis and Anticancer Activity of Thiadiazole Containing Thiourea, Benzothiazole and Imidazo[2,1-b][1,3,4]thiadiazole Scaffolds

Author(s): Stephen Paul Avvaru, Malleshappa N. Noolvi*, Uttam A More, Sudipta Chakraborty, Ashutosh Dash, Tejraj M Aminabhavi, Kumar P Narayan and Vishnu Sutariya
Pages: 1-16 (16)
Structure-Based Virtual Screening of New Benzoic Acid Derivatives as Trypanosoma cruzi Trans-sialidase Inhibitors

Author(s): Lenci Karina Vázquez-Jiménez, Alma Delia Paz-González, Alfredo Juárez-Saldivar, María Laura Uhrig, Rosalía Agusti, Alicia Reyes-Arellano, Benjamín Nogueda-Torres and Gildardo Rivera*
Pages: 1-8 (8)
Curcumin-based Antioxidant and Glycohydrolase Inhibitor Compounds: Synthesis and In Vitro Appraisal of the Dual Activity Against Diabetes

Author(s): Sajjad Esmaeili, Nazanin Ghobadi, Donya Nazari, Alireza Pourhossein, Hassan Rasouli, Hadi Adibi and Reza Khodarahmi*
Pages: 1-22 (22)
Synthesis, Anticancer, and Antibacterial Studies of Benzylidene Bearing 5-substituted and 3,5-disubstituted-2,4-Thiazolidinedione Derivatives

Author(s): Navjot Singh Sethi, Deo Nandan Prasad and Rajesh K. Singh*
Pages: 1-12 (12)
Synthesis of thiazolyl-N-phenylmorpholine Derivatives and their Biological Activities

Author(s): Amerah M. Al-Soliemy, Thoraya A. Farghaly, Eman M. H. Abbas, Mohamed R. Shaaban*, Mohie E. M. Zayed and Tarek B. A. El-Naggar
Pages: 1-16 (16)
Novel Aminopyrazole Tagged Hydrazones as Anti-Tubercular Agents: Synthesis and Molecular Docking Studies

Author(s): Thatavarthi Padmini, Darna Bhikshapathi, Kandagatla Suresh, Ravindra Kulkarni* and Bigala Raj Kamal
Pages: 1-8 (8)
Synthesis and Cytotoxic Activity of Novel Mono- and Bis-Indole Derivatives: Analogues of Marine Alkaloid Nortopsentin

Author(s): Mona Monir Kamel, Mohamed Kamal Abdel-hameid, Hala Bakr El-Nassan* and Eman Adel El-Khouly
Pages: 1-11 (11)
Synthesis of New Thioureas Derivatives and Evaluation of Their Efficacy as Proliferation Inhibitors in MCF-7 Breast Cancer Cells by Using 99mTc- MIBI Radiotracer

Author(s): Ahmad Hormati, Jafar Abbasi Shiran, Mikaeil Molazadeh, Babak Kaboudin and Sajjad Ahmadpour*
Pages: 1-13 (13)
Novel Conjugated Quinazolinone-Based Hydroxamic Acids: Design, Synthesis and Biological Evaluation

Author(s): Tran Khac Vu*, Nguyen Thi Thanh, Nguyen Van Minh, Nguyen Huong Linh, Nguyen Thi Phương Thao, Trương Thuc Bao Nguyen, Doan Thi Hien, Luu Van Chinh, Ta Hong Duc, Lai Duc Anh and Pham-The Hai
Pages: 1-18 (18)
Synthesis, Molecular Docking Studies and Antibacterial Activities of Novel Monocationic Indole-benzimidazole Derivatives

Author(s): Zeynep Ates-Alagoz*, Mehmet Murat Kisla, Hakan Goker and Sulhiye Yildiz
Pages: 1-8 (8)
Synthesis and Antimicrobial Activity of Novel 1, 2, 4-Triazolopyrimidofuro- quinazolinones from Natural Furochromones (Visnagenone and Khellinone)

Author(s): Ameen Ali Abu-Hashem*, Hoda A. R. Hussein and Ahmed S. Aly
Pages: 1-17 (17)
2,4-Thiazolidinedione as Precursor to the Synthesis of Compounds with Antiglioma Activities in C6 and GL261 Cells

Author(s): Alana de Vasconcelos, Ana Júlia Zulian Boeira, Bruna Bento Drawanz, Nathalia Stark Pedra, Natália Pontes Bona, Francieli Moro Stefanello and Wilson Cunico*
Pages: 1-10 (10)
Synthesis and Antioxidant Activity of New Selenium-Containing Quinolines

Author(s): Benedetta Bocchini, Bruna Goldani, Fernanda S.S. Sousa, Paloma T. Birmann, Cesar A. Brüning, Eder J. Lenardão, Claudio Santi, Lucielli Savegnago and Diego Alves*
Pages: 1-10 (10)
The Interaction of Schistosoma Japonicum Glutathione Transferase with Cibacron Blue 3GA and its Fragments

Author(s): Michalis Platis, Dimitrios Vlachakis, Ahmed Ibrahim Foudah, Magdy Mohamed Muharram, Mohamed Hamed Alqarni, Anastassios C. Papageorgiou and Nikolaos E. Labrou*
Pages: 1-12 (12)
Current Insights of Inhibitors of p38 Mitogen-Activated Protein Kinase in Inflammation

Author(s): Archana Awasthi, Mantripragada Bhagavan Raju and Md Azizur Rahman*
Pages: 1-21 (21)
Withdrawal Notice: The Design, Synthesis, Pharmacokinetic and Pharmacodynamic Evaluation of Acyloxyalkyl-substituted T705 Prodrugs

Author(s): Xingzhou Li, Tianhong Zhang and Wu Zhong
Pages: 1-1 (1)
New Approaches in Sensing and Targeting Bacterial rRNA A-site

Author(s): Preethi Parameswaran, Nihar Ranjan* and S.J.S. Flora*
Pages: 455-465 (11)
Phytochemical Screening, Cytotoxicity and Anti-inflammatory Activities of the Leaf Extracts from Lawsonia inermis of Indian Origin to Explore their Potential for Medicinal Uses

Author(s): Anju Manuja*, Nitu Rathore, Shalki Chaudhary and Balvinder Kumar
Pages: 1-11 (11)
Synthesis and Structure-activity Relationship of Aminoarylthiazole Derivatives as Potential Potentiators of the Chloride Transport Defect in Cystic Fibrosis

Author(s): Nara Liessi, Emanuela Pesce, Annalisa Salis, Gianluca Damonte, Bruno Tasso, Elena Cichero, Nicoletta Pedemonte and Enrico Millo*
Pages: 1-12 (12)
Synthesis, Antitrypanosomal and Antimycobacterial Activities of Coumarin N-acylhydrazonic Derivatives

Author(s): Camila Capelini, Vitória R. F. Câmara, José D. Figueroa Villar, Juliana M. C. Barbosa, Kelly Salomão, Solange L. de Castro, Policarpo A. Sales Junior, Silvane M. F. Murta, Thais B. Couto, Maria Cristina S. Lourenço, James L. Wardell, John N. Low, Edson F. da Silva and Samir A. Carvalho*
Pages: 1-8 (8)
Elucidating Molecular Interactions of Ten Natural Compounds Targeting E6 HPV High Risk Oncoproteins Using Microsecond Molecular Dynamics Simulations

Author(s): Thuluz Meza-Menchaca, Marcela Lizano-Soberón, Angel Trigos, Rossana C. Zepeda, Manuel E. Medina and Rodrigo Galindo-Murillo*
Pages: 1-14 (14)
A Comprehension into Target Binding and Spatial Fingerprints of Noscapinoid Analogues as Inhibitors of Tubulin

Author(s): Seema Mandavi, Renu Bhatt, Sant Kumar Verma, Laxmi Banjare, Amit Dubey, Suresh Thareja and Akhlesh Kumar Jain*
Pages: 1-12 (12)
Synthesis and 4D-QSAR Studies of Alanine Hydroxamic Acid Derivatives as Aminopeptidase N Inhibitors

Author(s): Min Gao, Qiao Li Lv, Hou Pan Zhang and Guo Gang Tu*
Pages: 1-9 (9)
“Microwave Assisted Synthesis and Molecular Docking Studies of Some 4 - (3H)-quinazolinone Derivatives as Inhibitors of Human Gamma- Aminobutyric Acid Receptor, the GABA (A)R-BETA3 Homopentamer”

Author(s): Amrutkar Rakesh Devidas* and Mahendra Sing Ranawat
Pages: 1-9 (9)
Synthesis and Evaluation of 5-imino-4-thioxoimidazolidin-2-one Derivatives as Antibacterial and Antifungal Agents

Author(s): Samir Y. Abbas*, Marwa A. M. Sh. El-Sharief, Reem A. K. Al-Harbi, Eman W. El-Gammal and Ahmed M. Sh. El-Sharief
Pages: 1-8 (8)
Synthesized 2-Trifluoromethylquinazolines and Quinazolinones Protect BV2 and N2a Cells against LPS- and H2O2-induced Cytotoxicity

Author(s): Neeranjini Nallathamby, Chia-Wei Phan, Matej Sova, Luciano Saso and Vikineswary Sabaratnam*
Pages: 1-7 (7)
Cytotoxicity, Docking Study of New Fluorinated Fused Pyrimidine Scaffold: Thermal and Microwave Irradiation Synthesis

Author(s): Alaa M. Abo Alnaja, Thoraya. A. Farghaly*, Heba S. A. El-zahabi and Mohamed R. Shaaban
Pages: 1-18 (18)
Study on the Interaction of 1,5-diaryl Pyrrole Derivatives with α- glucosidase; Synthesis, Molecular Docking, and Kinetic Study

Author(s): Tadesse Bekele Tafesse, Ebrahim Saeedian Moghadam, Mohammed Hussen Bule, Mohammad Ali Faramarzi, Mohammad Abdollahi and Mohsen Amini*
Pages: 1-9 (9)
Anti-Cholinesterase Activity of Chalcone Derivatives: Synthesis, In Vitro Assay and Molecular Docking Study

Author(s): Florentinus D.O. Riswanto, Mira S.A. Rawa, Vikneswaran Murugaiyah, Nurul H. Salin, Enade P. Istyastono, Maywan Hariono and Habibah A. Wahab*
Pages: 1-11 (11)
Activity of (-)-Camphene Derivatives Against Mycobacterium tuberculosis in Acidic pH

Author(s): Hayalla Corrêa de Carvalho, Andressa Lorena Ieque, Tamires Leite Valverde, Vanessa Pietrowski Baldin, Jean Eduardo Meneguello, Paula Aline Zanetti Campanerut-Sá, Fábio Vandresen, Luciana Dias Ghiraldi Lopes, Mariana Regina Passos Souza, Nathally Claudiane de Souza Santos, Vera Lucia Dias Siqueira, Katiany Rizzieri Caleffi-Ferracioli, Regiane Bertin Lima Scodro and Rosilene Fressatti Cardoso*
Pages: 1-8 (8)
Synthesis, Characterization, Antioxidant Activity of β-diketonates, and Effects of Coordination to Copper(II) ion on Their Activity: DNA, BSA Interactions and Molecular Docking Study

Author(s): Nenad Joksimović, Jelena Petronijević, Nenad Janković, Marijana Kosanić, Dušan Milivojević, Milan Vraneš, Aleksandar Tot and Zorica Bugarčić*
Pages: 1-14 (14)
Synthesis and Biological Evaluation of Matrine Derivatives as a Novel Family of Potential Anticancer Agents

Author(s): Jing Wang, Hang Liu, Xiao-Bin Zhuo, Guang-Ming Ye and Qing-Jie Zhao
Pages: 1-8 (8)
Design of Arylsulfonylhydrazones as Potential FabH Inhibitors: Synthesis, Antimicrobial Evaluation and Molecular Docking

Author(s): Thais Batista Fernandes, Natanael Dante Segretti, Felipe Rebello Lourenço, Thalita Marcílio Cândido, André Rolim Baby, Euzébio Guimarães Barbosa and Roberto Parise-Filho*
Pages: 1-11 (11)
A Study on Synthesis and Antioxidant Activity Comparison of Novel Stilbenebenzamide Compounds

Author(s): Aleksandra Kładna, Paweł Berczyński, Oya Bozdağ Dündar, Irena Kruk, Beyza Torun and Hassan Y. Aboul-Enein*
Pages: 1-12 (12)
Quantitative Structure Activity/pharmacokinetics Relationship Studies of HIV-1 Protease Inhibitors Using Three Modelling Methods

Author(s): Dan Han, Jianjun Tan*, Jingrui Men, Chunhua Li and Xiaoyi Zhang
Pages: 1-11 (11)
Synthesis and Evaluation of Aryl Substituted Propyl Piperazines for Potential Atypical Antipsychotic Activity

Author(s): Shalu Singh, Alka Bali* and Tania Peshin
Pages: 1-13 (13)
Synthesis, Antimicrobial Evaluation and Docking Study of Novel 3,5- Disubstituted-2-Isoxazoline and 1,3,5-Trisubstituted-2-Pyrazoline Derivatives

Author(s): Ahmed Hussein Ismail, Ahmed Mutanabbi Abdula, Ivan H.R. Tomi, Ali Hussein R. Al-Daraji and Younis Baqi*
Pages: 1-12 (12)

E-Pub Full Text Articles

2, 4, 5-Trideoxyhexopyranosides Derivatives of 4’-Demethylepipodophyllotoxin: De novo Synthesis and Anticancer Activity

Design, Synthesis, and Pharmacokinetic Evaluation of O-Carbamoyl Tizoxanide Prodrugs

Synthesis, Cytotoxicity, Anti-migration and Anti-invasion Activity of Diphyllin Heterocyclic Derivatives

Synthesis of N-acyl Derivatives of Aminocombretastatin A-4 and Study of their Interaction with Tubulin and downregulation of c-Myc

Site-directed Fragnomics and MD Simulations Approaches to Identify Interleukin-2 Inhibitors

Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry

Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents

Computational Study and Synthesis of a New Class of Anticonvulsants with 6 Hz Psychomotor Seizure Test Activity: 2-(1,3-benzodioxol-5-yloxy)- N'-[substituted]-acetohydrazides

Exploring the Selectivity Profile of Sigma Receptor Ligands by Molecular Docking and Pharmacophore Analyses

Anti-oxidant and Antiproliferative Activities of Mongolian Medicinal Plant Extracts and Structure Isolation of Gnetin - H Compound

Synthesis and Clinical Development of Palbociclib: An overview

Multi-target Directed Compounds with Antioxidant and/or Antiinflammatory Properties as Potent Agents for Alzheimer’s Disease

Antidiabetic and Antioxidative Properties of Novel Zn(II)-cinnamic Acid Complex

Exploring the Molecular Mechanisms of 17β-HSD5-induced Carcinogenicity of Catha edulis via Molecular Modeling Approach

Voltage-Dependent Sodium Channel Blocker Anticonvulsants: An Approach to the Structure-Activity Relationship

Design and Synthesis of Novel Anti-inflammatory/Anti-ulcer Hybrid Molecules with Antioxidant Activity

Synthesis and biological evaluation of 4-aminoantipyrine analogues

A New Series of Triazolothiadiazines as Potential Anticancer Agents for Targeted Therapy of Non-small Cell Lung and Colorectal Cancers: Design, Synthesis, In silico and In vitro Studies Providing Mechanistic Insight into their Anticancer Potencies

Chemical IN04 Inhibits the Kinase Domain not the ROC Domain of LRRK1: Results from Homology Modeling and Molecular Docking

Synthesis, Biological Evaluation, and QPLD Studies of Piperazine Derivatives as Potential DPP-IV Inhibitors

Synthesis, Characterization and Biological Studies of Organoselenium trans-Palladium(II) Complexes

Novel 4-Oxo-4,10-dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine-3-carboxylic Acid Derivatives as HIV-1 Integrase Inhibitors: Synthesis, Docking Studies, Molecular Dynamics Simulation and Biological Activities

Identification and Expression Analysis of CD73 Inhibitors in Cervical Cancer

Design, Synthesis, and Anti-Neuroinflammatory Activity of Amide- Containing Dithiolethiones

Evaluation of Ligustrazine-Based Synthetic Compounds for their Antiproliferative Effects

Oreganum Vulgare: In-vitro Assessment of Cytotoxicity, Molecular Docking Studies, Antioxidant and Anti-inflammatory Activity in LPS Stimulated RAW 264.7 Cells

Synthesis and Evaluation of Cytotoxicity of Novel Coumarin Peptide Alcohol Derivatives

Synthesis and in vitro anti-HCV and Antitumor Evaluation of Schisandronic Acid Derivatives

Indane-1,3-diones: As Potential and Selective α-glucosidase Inhibitors, their Synthesis, in vitro and in silico Studies

Design, Synthesis, Pharmacological evaluation, in silico modeling, prediction of toxicity and metabolism studies of novel 1-(substituted)-2-methyl-3-(4-oxo-2-phenyl quinazolin-3(4H)-yl)isothioureas

Synthesis and Structure-Activity Relationshπip Studies of N-monosubstituted Aroylthioureas as Urease Inhibitors

Natural Naphthoquinones Naphthoquinone-based Hydrazone Hybrids: Synthesis and Potent Activity Against Cancer Cell Lines

In silico Study to Evaluate the Antiviral Activity of Novel Structures against 3C-like Protease of Novel Coronavirus (COVID-19) and SARSCoV

Xanthone: A Promising Antimycobacterial Scaffold

Chalcones: As Potent α-amylase Enzyme Inhibitors; Synthesis, In Vitro, and In Silico Studies

Design and Synthesis of Arylnaphthalene Lignan Lactone Derivatives as Potent Topoisomerase Inhibitors

Spiro Heterocyclic Compounds as Potential Anti-Alzheimer Agents (Part 2): Their Metal Chelation Capacity, POM Analyses and DFT Studies

Synthesis of Novel 1,2,3-Triazole Derivatives of Isocoumarins and 3,4- Dihydroisocoumarin with Potential Antiplasmodial Activity In Vitro

Pyrazole Derivatives of Medically Relevant Phenolic Acids: Insight into Antioxidative and Anti-LOX Activity

Synthesis and Anticancer Activity of Thiadiazole Containing Thiourea, Benzothiazole and Imidazo[2,1-b][1,3,4]thiadiazole Scaffolds

Structure-Based Virtual Screening of New Benzoic Acid Derivatives as Trypanosoma cruzi Trans-sialidase Inhibitors

Curcumin-based Antioxidant and Glycohydrolase Inhibitor Compounds: Synthesis and In Vitro Appraisal of the Dual Activity Against Diabetes

Synthesis, Anticancer, and Antibacterial Studies of Benzylidene Bearing 5-substituted and 3,5-disubstituted-2,4-Thiazolidinedione Derivatives

Synthesis of thiazolyl-N-phenylmorpholine Derivatives and their Biological Activities

Novel Aminopyrazole Tagged Hydrazones as Anti-Tubercular Agents: Synthesis and Molecular Docking Studies

Synthesis and Cytotoxic Activity of Novel Mono- and Bis-Indole Derivatives: Analogues of Marine Alkaloid Nortopsentin

Synthesis of New Thioureas Derivatives and Evaluation of Their Efficacy as Proliferation Inhibitors in MCF-7 Breast Cancer Cells by Using 99mTc- MIBI Radiotracer

Novel Conjugated Quinazolinone-Based Hydroxamic Acids: Design, Synthesis and Biological Evaluation

Synthesis, Molecular Docking Studies and Antibacterial Activities of Novel Monocationic Indole-benzimidazole Derivatives

Synthesis and Antimicrobial Activity of Novel 1, 2, 4-Triazolopyrimidofuro- quinazolinones from Natural Furochromones (Visnagenone and Khellinone)

2,4-Thiazolidinedione as Precursor to the Synthesis of Compounds with Antiglioma Activities in C6 and GL261 Cells

Synthesis and Antioxidant Activity of New Selenium-Containing Quinolines

The Interaction of Schistosoma Japonicum Glutathione Transferase with Cibacron Blue 3GA and its Fragments

Current Insights of Inhibitors of p38 Mitogen-Activated Protein Kinase in Inflammation

Withdrawal Notice: The Design, Synthesis, Pharmacokinetic and Pharmacodynamic Evaluation of Acyloxyalkyl-substituted T705 Prodrugs

New Approaches in Sensing and Targeting Bacterial rRNA A-site

Phytochemical Screening, Cytotoxicity and Anti-inflammatory Activities of the Leaf Extracts from Lawsonia inermis of Indian Origin to Explore their Potential for Medicinal Uses

Synthesis and Structure-activity Relationship of Aminoarylthiazole Derivatives as Potential Potentiators of the Chloride Transport Defect in Cystic Fibrosis

Synthesis, Antitrypanosomal and Antimycobacterial Activities of Coumarin N-acylhydrazonic Derivatives

Elucidating Molecular Interactions of Ten Natural Compounds Targeting E6 HPV High Risk Oncoproteins Using Microsecond Molecular Dynamics Simulations

A Comprehension into Target Binding and Spatial Fingerprints of Noscapinoid Analogues as Inhibitors of Tubulin

Synthesis and 4D-QSAR Studies of Alanine Hydroxamic Acid Derivatives as Aminopeptidase N Inhibitors

“Microwave Assisted Synthesis and Molecular Docking Studies of Some 4 - (3H)-quinazolinone Derivatives as Inhibitors of Human Gamma- Aminobutyric Acid Receptor, the GABA (A)R-BETA3 Homopentamer”

Synthesis and Evaluation of 5-imino-4-thioxoimidazolidin-2-one Derivatives as Antibacterial and Antifungal Agents

Synthesized 2-Trifluoromethylquinazolines and Quinazolinones Protect BV2 and N2a Cells against LPS- and H2O2-induced Cytotoxicity

Cytotoxicity, Docking Study of New Fluorinated Fused Pyrimidine Scaffold: Thermal and Microwave Irradiation Synthesis

Study on the Interaction of 1,5-diaryl Pyrrole Derivatives with α- glucosidase; Synthesis, Molecular Docking, and Kinetic Study

Anti-Cholinesterase Activity of Chalcone Derivatives: Synthesis, In Vitro Assay and Molecular Docking Study

Activity of (-)-Camphene Derivatives Against Mycobacterium tuberculosis in Acidic pH

Synthesis, Characterization, Antioxidant Activity of β-diketonates, and Effects of Coordination to Copper(II) ion on Their Activity: DNA, BSA Interactions and Molecular Docking Study

Synthesis and Biological Evaluation of Matrine Derivatives as a Novel Family of Potential Anticancer Agents

Design of Arylsulfonylhydrazones as Potential FabH Inhibitors: Synthesis, Antimicrobial Evaluation and Molecular Docking

A Study on Synthesis and Antioxidant Activity Comparison of Novel Stilbenebenzamide Compounds

Quantitative Structure Activity/pharmacokinetics Relationship Studies of HIV-1 Protease Inhibitors Using Three Modelling Methods

Synthesis and Evaluation of Aryl Substituted Propyl Piperazines for Potential Atypical Antipsychotic Activity

Synthesis, Antimicrobial Evaluation and Docking Study of Novel 3,5- Disubstituted-2-Isoxazoline and 1,3,5-Trisubstituted-2-Pyrazoline Derivatives